Safety assessment of coleopteran active IPD072Aa protein from Psuedomonas chlororaphis.

Autor: Carlson AB; Corteva Agriscience™ Agriculture Division of DowDuPont™, 8325 NW 62nd Avenue, Johnston, IA 50131, USA., Mathesius CA; Corteva Agriscience™ Agriculture Division of DowDuPont™, 8325 NW 62nd Avenue, Johnston, IA 50131, USA. Electronic address: carey.mathesius@corteva.com., Ballou S; Corteva Agriscience™ Agriculture Division of DowDuPont™, 8325 NW 62nd Avenue, Johnston, IA 50131, USA., Boeckman CJ; Corteva Agriscience™ Agriculture Division of DowDuPont™, 8325 NW 62nd Avenue, Johnston, IA 50131, USA., Gunderson TA; Corteva Agriscience™ Agriculture Division of DowDuPont™, 8325 NW 62nd Avenue, Johnston, IA 50131, USA., Mirsky HP; Corteva Agriscience™ Agriculture Division of DowDuPont™, 8325 NW 62nd Avenue, Johnston, IA 50131, USA., Mukerji P; Corteva Agriscience™ Agriculture Division of DowDuPont™ Haskell Global Center for Health Sciences, P.O. Box 30, Newark, DE 19714, USA., Roe JC; Corteva Agriscience™ Agriculture Division of DowDuPont™, 8325 NW 62nd Avenue, Johnston, IA 50131, USA., Schmidt JM; Corteva Agriscience™ Agriculture Division of DowDuPont™, 8325 NW 62nd Avenue, Johnston, IA 50131, USA., Zhang J; Corteva Agriscience™ Agriculture Division of DowDuPont™, 8325 NW 62nd Avenue, Johnston, IA 50131, USA., Delaney B; Corteva Agriscience™ Agriculture Division of DowDuPont™, 8325 NW 62nd Avenue, Johnston, IA 50131, USA.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2019 Jul; Vol. 129, pp. 376-381. Date of Electronic Publication: 2019 May 02.
DOI: 10.1016/j.fct.2019.04.055
Abstrakt: The ipd072Aa gene from Pseudomonas chlororaphis encodes the IPD072Aa protein which confers protection against certain coleopteran pests when expressed in genetically modified (GM) plants. A weight of evidence approach was used to assess the safety of the IPD072Aa protein. This approach considered the history of safe use of the source organism and bioinformatic comparison of the protein sequence with known allergenic and toxic proteins. The IPD072Aa protein was assessed for resistance to degradation in the presence of simulated gastric fluid containing pepsin as well as heat stability. There was no hazard identified with the IPD072Aa protein. Furthermore, an acute oral toxicity study found no evidence of adverse effects. Collectively, these studies support the human health safety assessment of the IPD072Aa protein.
(Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: