VIP Interneurons Contribute to Avoidance Behavior by Regulating Information Flow across Hippocampal-Prefrontal Networks.

Autor:	Lee AT; Department of Psychiatry, Weill Institute for Neuroscience, Kavli Institute for Fundamental Neuroscience, and Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA., Cunniff MM; Department of Psychiatry, Weill Institute for Neuroscience, Kavli Institute for Fundamental Neuroscience, and Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA., See JZ; Department of Psychiatry, Weill Institute for Neuroscience, Kavli Institute for Fundamental Neuroscience, and Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA., Wilke SA; Department of Psychiatry, Weill Institute for Neuroscience, Kavli Institute for Fundamental Neuroscience, and Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA., Luongo FJ; Department of Psychiatry, Weill Institute for Neuroscience, Kavli Institute for Fundamental Neuroscience, and Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA., Ellwood IT; Department of Psychiatry, Weill Institute for Neuroscience, Kavli Institute for Fundamental Neuroscience, and Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA., Ponnavolu S; Department of Psychiatry, Weill Institute for Neuroscience, Kavli Institute for Fundamental Neuroscience, and Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA., Sohal VS; Department of Psychiatry, Weill Institute for Neuroscience, Kavli Institute for Fundamental Neuroscience, and Sloan-Swartz Center for Theoretical Neurobiology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94143-0444, USA. Electronic address: vikaas.sohal@ucsf.edu.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2019 Jun 19; Vol. 102 (6), pp. 1223-1234.e4. Date of Electronic Publication: 2019 Apr 30.
DOI:	10.1016/j.neuron.2019.04.001
Abstrakt:	Inhibitory interneurons expressing vasoactive intestinal polypeptide (VIP) are known to disinhibit cortical neurons. However, it is unclear how disinhibition, occurring at the single-cell level, interacts with network-level patterns of activity to shape complex behaviors. To address this, we examined the role of prefrontal VIP interneurons in a widely studied mouse behavior: deciding whether to explore or avoid the open arms of an elevated plus maze. VIP interneuron activity increases in the open arms and disinhibits prefrontal responses to hippocampal inputs, which are known to transmit signals related to open arm avoidance. Indeed, inhibiting VIP interneurons disrupts network-level representations of the open arms and decreases open arm avoidance specifically when hippocampal-prefrontal theta synchrony is strong. Thus, VIP interneurons effectively gate the ability of hippocampal input to generate prefrontal representations, which drive avoidance behavior. This shows how VIP interneurons enable cortical circuits to integrate specific inputs into network-level representations that guide complex behaviors. VIDEO ABSTRACT. (Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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