Toxicity Studies of Chanoclavine in Mice.

Autor: Finch SC; AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand. sarah.finch@agresearch.co.nz., Munday JS; Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11 222, Palmerston North 4442, New Zealand. J.Munday@massey.ac.nz., Sprosen JM; AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand. jan.sprosen@agresearch.co.nz., Bhattarai S; AgResearch Limited, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New Zealand. sweta.bhattarai@agresearch.co.nz.
Jazyk: angličtina
Zdroj: Toxins [Toxins (Basel)] 2019 May 02; Vol. 11 (5). Date of Electronic Publication: 2019 May 02.
DOI: 10.3390/toxins11050249
Abstrakt: Epichloë endophytes have been used successfully in pastoral grasses providing protection against insect pests through the expression of secondary metabolites. This approach could be extended to other plant species, such as cereals, reducing reliance on pesticides. To be successful, the selected endophyte must express secondary metabolites that are active against cereal insect pests without any secondary metabolite, which is harmful to animals. Chanoclavine is of interest as it is commonly expressed by endophytes and has potential insecticidal activity. Investigation of possible mammalian toxicity is therefore required. An acute oral toxicity study showed the median lethal dose of chanoclavine to be >2000 mg/kg. This allows it to be classified as category 5 using the globally harmonized system of classification and labelling of chemicals, and category 6.1E using the New Zealand Hazardous Substances and New Organisms (HSNO) hazard classes, the lowest hazard class under both systems of classification. A three-week feeding study was also performed, which showed chanoclavine, at a dose rate of 123.9 mg/kg/day, initially reduced food consumption but was resolved by day seven. No toxicologically significant effects on gross pathology, histology, hematology, or blood chemistry were observed. These experiments showed chanoclavine to be of low toxicity and raised no food safety concerns.
Databáze: MEDLINE
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