A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies.
| Autor: | Yusoff AAM; Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia., Abdullah WSW; Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia., Khair SZNM; Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia., Radzak SMA; Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. |
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| Jazyk: | angličtina |
| Zdroj: | Oncology reviews [Oncol Rev] 2019 Apr 16; Vol. 13 (1), pp. 409. Date of Electronic Publication: 2019 Apr 16 (Print Publication: 2019). |
| DOI: | 10.4081/oncol.2019.409 |
| Abstrakt: | Mitochondria are cellular machines essential for energy production. The biogenesis of mitochondria is a highly complex and it depends on the coordination of the nuclear and mitochondrial genome. Mitochondrial DNA (mtDNA) mutations and deletions are suspected to be associated with carcinogenesis. The most described mtDNA deletion in various human cancers is called the 4977-bp common deletion (mDNA 4977 ) and it has been explored since two decades. In spite of that, its implication in carcinogenesis still unknown and its predictive and prognostic impact remains controversial. This review article provides an overview of some of the cellular and molecular mechanisms underlying mDNA 4977 formation and a detailed summary about mDNA 4977 reported in various types of cancers. The current knowledges of mDNA 4977 as a prognostic and predictive marker are also discussed. Competing Interests: Conflict of interest: the author declares no potential conflict of interest. |
| Databáze: | MEDLINE |
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