Altered superoxide dismutase-1 activity and intercellular adhesion molecule 1 (ICAM-1) levels in patients with type 2 diabetes mellitus.

Autor: Tavares AM; Programa de pós graduação em Ciências Médicas, Universidade Federal Fluminense, Niterói, RJ, Brasil., Silva JH; Escola de Biologia, Universidade Salgado de Oliveira (UNIVERSO), Niterói, RJ, Brasil., Bensusan CO; Programa de pós graduação em Ciências Médicas, Universidade Federal Fluminense, Niterói, RJ, Brasil., Ferreira ACF; Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.; Multidisciplinary Center for Biological Research (Numpex-Bio), Universidade Federal do Rio de Janeiro, Duque de Caxias, RJ, Brasil., Matos LPL; Departamento de Ciências Básicas, Universidade Federal Fluminense, Nova Friburgo, RJ, Brasil., E Souza KLA; Multidisciplinary Center for Biological Research (Numpex-Bio), Universidade Federal do Rio de Janeiro, Duque de Caxias, RJ, Brasil., Cardoso-Weide LC; Departamento de Patologia, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brasil., Taboada GF; Departamento de Medicina Clínica, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ, Brasil.; Faculdade de Medicina, Universidade Estácio de Sá, Rio de Janeiro, RJ, Brasil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2019 May 01; Vol. 14 (5), pp. e0216256. Date of Electronic Publication: 2019 May 01 (Print Publication: 2019).
DOI: 10.1371/journal.pone.0216256
Abstrakt: Inflammation and oxidative stress are linked to type 2 diabetes mellitus (T2DM). In this work, we analyzed patients' blood markers of antioxidant capacity, oxidative stress and inflammation in individuals with T2DM, in pre-diabetes state (pre-DM) and controls without diabetes. Patients were divided into three groups, according to glycated hemoglobin A1c (HbA1c): <7%, 7-9%, and >9%. Superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities, total thiols, nitric oxide (•NO), tumor necrosis factor alpha (TNF-α) and intercellular adhesion molecule 1 (ICAM-1) levels of the individuals were measured. Plasma SOD activity was higher in T2DM subjects compared to the controls. While total thiols levels were lower in T2DM groups when compared to pre-DM, the values remained unchanged when compared to controls. ICAM-1 levels of T2DM groups were lower than in controls, while GPx activity, •NO, and TNF-α levels were similar among all groups. A positive correlation was found between SOD and HbA1c levels. Concluding, individuals with T2DM present altered SOD activity, total thiols, and ICAM-1 levels, which might contribute to further complications. There is a positive correlation between SOD activity and HbA1c levels. No apparent correlation exists between total thiols and ICAM-1 levels and with any other of the parameters evaluated in this study.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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