Association between inflammatory markers and hospitalizations: evidence from the Bambuí cohort of aging baseline.

Autor:	Cosso RMG; Fundação Oswaldo Cruz, Centro de Pesquisas René Rachou - Belo Horizonte (MG), Brasil., Torres KCL; Fundação Oswaldo Cruz, Centro de Pesquisas René Rachou - Belo Horizonte (MG), Brasil., Mambrini JVM; Fundação Oswaldo Cruz, Centro de Pesquisas René Rachou - Belo Horizonte (MG), Brasil., Peixoto SWV; Fundação Oswaldo Cruz, Centro de Pesquisas René Rachou - Belo Horizonte (MG), Brasil., Carvalho AT; Fundação Oswaldo Cruz, Centro de Pesquisas René Rachou - Belo Horizonte (MG), Brasil., Martins Filho OA; Fundação Oswaldo Cruz, Centro de Pesquisas René Rachou - Belo Horizonte (MG), Brasil., Lima-Costa MF; Fundação Oswaldo Cruz, Centro de Pesquisas René Rachou - Belo Horizonte (MG), Brasil.
Jazyk:	Portuguese; English
Zdroj:	Revista brasileira de epidemiologia = Brazilian journal of epidemiology [Rev Bras Epidemiol] 2019; Vol. 22, pp. e190039. Date of Electronic Publication: 2019 Apr 29.
DOI:	10.1590/1980-549720190039
Abstrakt:	Introduction: Inflammation plays an important role in the aging process. Objective: This cross-sectional study aims to examine the association between inflammatory markers and hospitalizations among older adults, considering as potential confounding factors the predisposing and enabling factors for the use of health services and health conditions. Methods: We used data from 1,393 participants (≥ 60 years) in the baseline cohort from Bambuí. The markers assessed were ten cytokines and chemokines [interleukin (IL)-1, IL-6, IL-10, IL-12, tumor necrosis factor (TNF), CCL2, CCL5, CXCL8, CXCL9, and CXCL10]. The outcome variable was one or more hospitalizations in the preceding 12 months. Results: Elevated serum levels of IL-6 were significantly associated with hospitalizations [prevalence ratio (PR) = 1.38; confidence interval of 95% (95%CI) 1.02 - 1.87 and PR = 1.38; 95%CI 1.01 - 1.88 for the intermediate and highest tertiles, respectively]. High levels of CXCL9 were also independently associated with the outcome (PR = 1.38; 95%CI 1.01 - 1.89 and PR = 1.46; 95%CI 1.07 - 2.00, respectively). Other markers showed no statistically significant association with hospitalizations. Conclusion: Among the ten markers analyzed, only IL-6 and CXCL9 were associated with hospitalizations.
Databáze:	MEDLINE
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