pH-responsive chitosan based hydrogels affect the release of dapsone: Design, set-up, and physicochemical characterization.

Autor: Chaves LL; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal., Silveri A; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal; Department of Pharmacy, University of Chieti - Pescara 'G. d'Annuzio', 66100 Chieti, Italy; Aptuit, Evotec Company, 37135 Verona, Italy., Vieira ACC; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal., Ferreira D; Laboratory of Pharmaceutical Technology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal., Cristiano MC; Department of Health Sciences, University of Catanzaro 'Magna Graecia', 88100 Catanzaro, Italy., Paolino D; Department of Clinical and Experimental Medicine, University of Catanzaro 'Magna Graecia', 88100 Catanzaro, Italy., Di Marzio L; Department of Pharmacy, University of Chieti - Pescara 'G. d'Annuzio', 66100 Chieti, Italy., Lima SC; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal., Reis S; LAQV-REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal. Electronic address: shreis@ff.up.pt., Sarmento B; i3S Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, University of Porto, 4200-135 Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, 4585-116 Gandra, Portugal. Electronic address: bruno.sarmento@ineb.up.pt., Celia C; Department of Pharmacy, University of Chieti - Pescara 'G. d'Annuzio', 66100 Chieti, Italy; Department of Nanomedicine, Houston Methodist Research Institute, 77030 Houston, TX, USA. Electronic address: c.celia@unich.it.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2019 Jul 15; Vol. 133, pp. 1268-1279. Date of Electronic Publication: 2019 Apr 26.
DOI: 10.1016/j.ijbiomac.2019.04.178
Abstrakt: Dapsone (DAP) is a bactericidal agent used in the treatment of leprosy, caused by Mycobacterium leprae. Despite its therapeutic potential, DAP has low solubility, which results in allow therapeutic index and a high microbial resistance. Recently, new approaches were used to increase the DAP solubility. In particular, the use of interpenetrating polymer network (IPN)-hydrogels based chitosan (CS) for the controlled release of DAP provides some advantages because they can modify their swelling properties and network structures as a response to environmental stimuli. The aim of this study was to synthesize and physicochemically characterize pH-responsive chitosan/polymer hydrogels to control the release of DAP. For this reason, different combination of polymers, such as polyvinyl pyrrolidone, polyethylene glycol and hydroxypropyl methylcellulose, and concentrations of the cross-linking agents (glutaraldehyde) were used and then blended to the CS. The resulting hydrogels were evaluated in terms of physicochemical and swelling properties, rheological analysis and in vitro release of DAP at different pHs (1.2-6.8). Hydrogels were further characterized by Fourier transformed infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM) analysis. pH-responsive DAP-loaded hydrogels may represent the set-up for developing potential oral formulations for the treatment of leprosy caused by Mycobacterium leprae.
(Copyright © 2019. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: