HLA genetic study from United Arab Emirates (UAE), Abu Dhabi.

Autor: Arnaiz-Villena A; Department of Immunology, University Complutense, School of Medicine, Madrid, Spain. Electronic address: arnaizantonio@gmail.com., Yafei ZA; Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates., Juarez I; Department of Immunology, University Complutense, School of Medicine, Madrid, Spain., Palacio-Gruber J; Department of Immunology, University Complutense, School of Medicine, Madrid, Spain., Mahri AA; Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates., Alvares M; Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates., Lopez-Nares A; Department of Immunology, University Complutense, School of Medicine, Madrid, Spain., Nieto J; Department of Immunology, University Complutense, School of Medicine, Madrid, Spain., Al Seiari M; Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates., Martin-Villa JM; Department of Immunology, University Complutense, School of Medicine, Madrid, Spain., ElGhazali G; Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.
Jazyk: angličtina
Zdroj: Human immunology [Hum Immunol] 2019 Jul; Vol. 80 (7), pp. 421-422. Date of Electronic Publication: 2019 Apr 24.
DOI: 10.1016/j.humimm.2019.04.013
Abstrakt: Emiratis belong to the United Arab Emirates (UAE) country. UAE is placed at the East part of the Arabian Peninsula, protruding into the Arabia Gulf and was populated since 130,000 years ago. First humans migrating out of Africa went probably across this territory. HLA-A, -B, -C, -DRB1, -DQB1, -DQA1 were typed in order to obtain HLA profile for clinical, epidemiological and population genetics studies. Twenty different HLA-A, thirty-five HLA-B and twenty-two HLA-C class I alleles were detected; twenty-seven different HLA-DRB1, fourteen HLA-DQB1 and twelve HLA-DQA1 class II alleles were found. Most frequent extended HLA haplotypes are also depicted. People are present in this area since prehistoric ages according to archaeological studies; the "Out of Africa" eastern migration may have affected the present day population composition.
(Copyright © 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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