Parental perinatal exposure to bisphenol A reduces the threshold to disrupt blastocyst implantation via decreasing talin, occudin and E-cadherin levels.

Autor: Martínez-Peña AA; Facultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico., Peña-Castillo A; Facultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico., Parra-Forero LY; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Ciudad de México 07360, Mexico., Hernández-Ochoa I; Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Ciudad de México 07360, Mexico., Hernández-Barrientos LR; Facultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico., Morimoto S; Instituto Nacional de Ciencias Médicas y de la Nutrición Salvador Zubirán, Ciudad de Mexico 14080, Mexico., Mendoza-Rodríguez CA; Facultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México, Ciudad de Mexico 04510, Mexico. Electronic address: adrimed@yahoo.com.
Jazyk: angličtina
Zdroj: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2019 Jun; Vol. 86, pp. 86-97. Date of Electronic Publication: 2019 Apr 24.
DOI: 10.1016/j.reprotox.2019.04.005
Abstrakt: The aim was to evaluate the effect of perinatal BPA exposure of one or both parents on the implantation index and expression of talin, occludin and E-cadherin in the uterine epithelial cells (UEC) of the offspring. Pregnant Wistar dams (F0) received BPA or vehicle from gestational day (GD) 6 to lactation day 21. F1 animals were mated forming four groups: Control dam-Control sire (C♀-C♂), BPA dam -Control sire (B♀-C♂), Control dam -BPA sire (C♀-B♂), BPA dam -BPA sire (B♀-B♂). F1 dams were sacrificed at GD 6. Significantly decreased number of implantation sites was observed in the B♀-B♂ group as compared to the C♀-C♂ group, which correlated with decreased talin apical/basal expression ratio, occludin apical expression, and E-cadherin apical/lateral expression ratio in the UEC. Furthermore, decreased E-cadherin expression in the blastocyst was observed. Our data suggest that reduced protein expressions in F1 BPA offspring could result from decreased progesterone serum levels.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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