Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion.
Autor: | Leyva-Castillo JM; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Galand C; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Kam C; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Burton O; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Gurish M; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Musser MA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA., Goldsmith JD; Department of Pathology, Boston Children's Hospital, Boston, MA, USA., Hait E; Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA., Nurko S; Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA., Brombacher F; International Center for Genetic Engineering and Biotechnology & University of Cape Town & South Africa Medical Research Council, South Africa., Dong C; Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China., Finkelman FD; Department of Internal Medicine and Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Lee RT; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Ziegler S; Immunology Program, Benaroya Research Institute, Seattle, WA, USA., Chiu I; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA., Austen KF; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Geha RS; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: raif.geha@childrens.harvard.edu. |
---|---|
Jazyk: | angličtina |
Zdroj: | Immunity [Immunity] 2019 May 21; Vol. 50 (5), pp. 1262-1275.e4. Date of Electronic Publication: 2019 Apr 23. |
DOI: | 10.1016/j.immuni.2019.03.023 |
Abstrakt: | Mast cell (MC) mediator release after crosslinking of surface-bound IgE antibody by ingested antigen underlies food allergy. However, IgE antibodies are not uniformly associated with food allergy, and intestinal MC load is an important determinant. Atopic dermatitis (AD), characterized by pruritis and cutaneous sensitization to allergens, including foods, is strongly associated with food allergy. Tape stripping mouse skin, a surrogate for scratching, caused expansion and activation of small intestinal MCs, increased intestinal permeability, and promoted food anaphylaxis in sensitized mice. Tape stripping caused keratinocytes to systemically release interleukin-33 (IL-33), which synergized with intestinal tuft-cell-derived IL-25 to drive the expansion and activation of intestinal type-2 innate lymphoid cells (ILC2s). These provided IL-4, which targeted MCs to expand in the intestine. Duodenal MCs were expanded in AD. In addition to promoting cutaneous sensitization to foods, scratching may promote food anaphylaxis in AD by expanding and activating intestinal MCs. (Copyright © 2019 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |