The autoimmune targets in IPEX are dominated by gut epithelial proteins.

Autor: Eriksson D; Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden; Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden. Electronic address: daniel.eriksson@ki.se., Bacchetta R; Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Stanford, Calif., Gunnarsson HI; Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden., Chan A; Department of Pediatrics, University of California San Francisco, San Francisco, Calif., Barzaghi F; San Raffaele Telethon Institute for Gene Therapy, Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ehl S; Center for Chronic Immunodeficiency, Freiburg University Hospital, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Hallgren Å; Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden., van Gool F; Diabetes Center, University of California San Francisco, San Francisco, Calif., Sardh F; Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden., Lundqvist C; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Laakso SM; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Rönnblom A; Department of Medical Sciences, Gastroenterology, Uppsala University, Uppsala, Sweden., Ekwall O; Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Mäkitie O; Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden; Folkhälsan Institute of Genetics and University of Helsinki, Helsinki, Finland., Bensing S; Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden., Husebye ES; Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden; Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, Bergen, Norway., Anderson M; Diabetes Center, University of California San Francisco, San Francisco, Calif., Kämpe O; Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden; Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden; K.G. Jebsen Center for Autoimmune Disorders, Bergen, Norway., Landegren N; Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Jazyk: angličtina
Zdroj: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2019 Jul; Vol. 144 (1), pp. 327-330.e8. Date of Electronic Publication: 2019 Apr 23.
DOI: 10.1016/j.jaci.2019.02.031
Databáze: MEDLINE