| Autor: |
Tikhonov DB; I.M. Sechenov Institute of Evolutinary Physiology and Biochemistry Russian Academy of Sciences, Thorez pr. 44, 194223, St.Petersburg, Russia., Magazanik LG; I.M. Sechenov Institute of Evolutinary Physiology and Biochemistry Russian Academy of Sciences, Thorez pr. 44, 194223, St.Petersburg, Russia., Nagaeva EI; I.M. Sechenov Institute of Evolutinary Physiology and Biochemistry Russian Academy of Sciences, Thorez pr. 44, 194223, St.Petersburg, Russia. |
| Abstrakt: |
The proton-gated cationic channels belonging to the ASIC family are widely distributed in the central nervous system of vertebrates and play an important role in several physiological and pathological processes. ASIC1a are most sensitive to acidification of the external medium, which is the reason for the current interest in their function and pharmacology. Recently, the list of ASIC1a ligands has been rapidly expanding. It includes inorganic cations, a large number of synthetic and endogenous small molecules, and peptide toxins. The information on the mechanisms of action and the binding sites of the ligands comes from electrophysiological, mutational and structural studies. In the present review, we attempt to present a systematic view of the complex pattern of interactions between ligands and ASIC1a. |
