Lycopene presence in facial skin corneocytes and sebum and its association with circulating lycopene isomer profile: Effects of age and dietary supplementation.

Autor: Petyaev IM; Lycotec Ltd Cambridge UK., Pristensky DV; Lycotec Ltd Cambridge UK., Morgunova EY; Gamaleya Research Institute of Epidemiology and Microbiology Moscow Russia., Zigangirova NA; Gamaleya Research Institute of Epidemiology and Microbiology Moscow Russia., Tsibezov VV; Gamaleya Research Institute of Epidemiology and Microbiology Moscow Russia., Chalyk NE; Saratov State Medical University Research Institute of Cardiology Saratov Russia., Klochkov VA; Saratov State Medical University Research Institute of Cardiology Saratov Russia., Blinova VV; Saratov State Medical University Research Institute of Cardiology Saratov Russia., Bogdanova TM; Saratov State Medical University Research Institute of Cardiology Saratov Russia., Iljin AA; Saratov State Medical University Research Institute of Cardiology Saratov Russia., Sulkovskaya LS; Saratov State Medical University Research Institute of Cardiology Saratov Russia., Chernyshova MP; Lycotec Ltd Cambridge UK., Lozbiakova MV; Lycotec Ltd Cambridge UK., Kyle NH; Lycotec Ltd Cambridge UK., Bashmakov YK; Lycotec Ltd Cambridge UK.
Jazyk: angličtina
Zdroj: Food science & nutrition [Food Sci Nutr] 2019 Mar 13; Vol. 7 (4), pp. 1157-1165. Date of Electronic Publication: 2019 Mar 13 (Print Publication: 2019).
DOI: 10.1002/fsn3.799
Abstrakt: Lycopene is a dietary antioxidant known to prevent skin photodamage. This study aimed to examine age-dependent presence of this carotenoid on the surface of the facial skin and in the serum as well as to measure the same parameters during supplementation with lycopene. Serum samples and samples from facial skin surface were obtained from 60 young (under 25 years old) and 60 middle-aged (over 50 years old) volunteers. Similar samples were taken from 15 middle-aged subjects during 4-week supplementation with lycopene (7 mg/day). Serum lycopene levels and isomer profiles were analyzed by HPLC. Lycopene in desquamated corneocytes and the sebum from facial skin surface was determined using lycopene-specific fluorescent monoclonal antibodies. The results demonstrated that there was no age-related difference in serum lycopene levels, but a higher proportion of (all-E)-lycopene was detected in the "young" group (37.5% vs 26.2% in the "middle-aged" group; p  <   0.0001). "Young" volunteers also had a higher lycopene level in both corneocytes ( p  =   0.0071) and the sebum ( p  =   0.0139) from the skin surface. Supplementation with lycopene resulted in a sharp increase of lycopene concentrations in both serum and skin surface samples. There was also a clear change in the pattern of lycopene isomers in the serum manifested by a significant increase in the proportion of (all-E)-lycopene (from 22.1% to 44.0% after supplementation, p  <   0.0001). It can be concluded that dietary supplementation with lycopene results in its accumulation in the serum and skin. This process is accompanied by significant changes in the circulating lycopene isomer profile which becomes similar to that typical for young individuals.
Competing Interests: Lycotec Ltd developed GA Lycopene, which is evaluated in this study. Ivan M. Petyaev and Nigel H. Kyle are employees of Lycotec; Dmitry V. Pristensky, Marina P. Chernyshova, Marina V. Lozbiakova, and Yuriy K. Bashmakov are independent scientists who collaborate with, but are not, and have never been employees of Lycotec; Natalya E. Chalyk, Victor A. Klochkov, Victoria V. Blinova, Tatiana M. Bogdanova, Alexei A. Iljin, Larisa S. Sulkovskaya and are employees of the Institute of Cardiology in Saratov, Russian Federation; Elena Y. Morgunova, Nailya A. Zigangirova and Valeriy V. Tsibezov are employees of the Gamaleya Research Institute of Epidemiology and Microbiology in Moscow, Russian Federation. There have never been any financial relationships between Lycotec and these collaborating organisations.
Databáze: MEDLINE
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