Tenofovir concentrations in hair strongly predict virologic suppression in breastfeeding women.

Autor:	Murnane PM; Department of Medicine, Center for AIDS Prevention Studies., Bacchetti P; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco., Currier JS; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California., Brummel S; Center for Biostatistics in AIDS Research, T.H. Chan School of Public Health, Harvard University, Cambridge, Massachusetts., Okochi H; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine., Phung N; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA., Louie A; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA., Kuncze K; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA., Hoffman RM; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California., Nematadzira T; Clinical Trials Research Centre, University of Zimbabwe College of Health Sciences, Harare, Zimbabwe., Soko DK; College of Medicine-Johns Hopkins Research Project, Blantyre, Malawi., Owor M; Makerere University-Johns Hopkins University Research Collaboration, Kampala, Uganda., Saidi F; University of North Carolina-Lilongwe, Lilongwe, Malawi., Flynn PM; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee., Fowler MG; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Gandhi M; Division of HIV, Infectious Diseases, and Global Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California, USA.
Jazyk:	angličtina
Zdroj:	AIDS (London, England) [AIDS] 2019 Aug 01; Vol. 33 (10), pp. 1657-1662.
DOI:	10.1097/QAD.0000000000002237
Abstrakt:	Background: Antiretroviral treatment (ART) adherence is often suboptimal in the perinatal period. We measured hair tenofovir (TFV) concentrations as a metric of adherence in postpartum women to understand patterns and predictors of adherence throughout this critical period. In addition, we examined the association between hair TFV concentrations and virologic outcomes. Methods: Between 12/2012 and 09/2016, hair samples were collected longitudinally from delivery through breastfeeding from women on ART in the Promoting Maternal and Infant Survival Everywhere study (NCT01061151) in sub-Saharan Africa. Hair TFV levels were measured using validated methods. Using generalized estimating equations, we estimated the association between hair TFV levels and virologic suppression (<400 copies/ml) over time and assessed predictors of hair TFV levels. Results: Hair TFV levels were measured at 370 visits in 71 women from delivery through a median of 14 months (interquartile range 12-15) of breastfeeding. Levels ranged from below detection (0.002) to 1.067 ng/mg (geometric mean: 0.047). After at least 90 days on ART, 69 women had at least one viral load measured (median 5 measures, range 1-9); 18 (26%) experienced viremia at least once. Each doubling of TFV level more than doubled odds of concurrent virologic suppression [odds ratio 2.35, 95% confidence interval (CI): 1.44-3.84, P = 0.0006] and was associated with 1.43 times the odds of future suppression (95% CI: 0.75-2.73, P = 0.28). Relative to the first 3 months after delivery, hair levels were highest in months 6-12 (1.42-fold higher, 95% CI: 1.09-1.85, P = 0.01). Conclusion: Hair TFV levels strongly predicted concurrent virologic suppression among breastfeeding women. Objective adherence metrics can supplement virologic monitoring to optimize treatment outcomes in this important transition period.
Databáze:	MEDLINE
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