Prostate cancer dose-response, fractionation sensitivity and repopulation parameters evaluation from 25 international radiotherapy outcome data sets.
Autor: | Tamponi M; 1 ATS, Sardinia Regional Health Service , Sassari , Italy., Gabriele D; 2 Institute of Radiological Sciences University of Sassari , Italy., Maggio A; 3 Medical Physics, Candiolo Cancer Institute - FPO , IRCCS, Candiolo (To) , Italy., Stasi M; 3 Medical Physics, Candiolo Cancer Institute - FPO , IRCCS, Candiolo (To) , Italy., Meloni GB; 2 Institute of Radiological Sciences University of Sassari , Italy., Conti M; 2 Institute of Radiological Sciences University of Sassari , Italy.; 4 Department of Diagnostic Imaging, AOU, University Hospital Trust of Sassari , Italy., Gabriele P; 5 Radiation Therapy, Candiolo Cancer Institute - FPO , IRCCS, Candiolo (To) , Italy. |
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Jazyk: | angličtina |
Zdroj: | The British journal of radiology [Br J Radiol] 2019 Jun; Vol. 92 (1098), pp. 20180823. Date of Electronic Publication: 2019 Apr 24. |
DOI: | 10.1259/bjr.20180823 |
Abstrakt: | Objective: This study was undertaken to model the biochemical free survival at 5 years and to evaluate the parameters defining dose-response curve, dose-fractionation radiosensitivity and repopulation. Methods: It was carried out a literature search on Pubmed to retrieve data sets of patients treated with external beam radiation therapy of 1.8-4.0 Gy per fraction and overall treatment time of 3 to 10 weeks. 10 groups were identified, based on risk class and androgen deprivation therapy (ADT). Dose-response curve D Results: 25 data sets, including 20,310 patients, were considered. The median (95% CI) D Conclusion: Dose-response curve resulted dependent on risk class and ADT, with higher steepness for no-ADT patients. Low values of dose-fractionation radiosensitivity were found, supporting the use of moderate hypofractionated radiotherapy in each risk class. A limited dependence on repopulation was observed. Advances in Knowledge: Prostate cancer response to moderate hypofractionated radiotherapy was reliably quantified considering risk class and androgen deprivation therapy. |
Databáze: | MEDLINE |
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