Regulation of Drosophila germline stem cells.

Autor: Kahney EW; Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA., Snedeker JC; Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA., Chen X; Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA. Electronic address: xchen32@jhu.edu.
Jazyk: angličtina
Zdroj: Current opinion in cell biology [Curr Opin Cell Biol] 2019 Oct; Vol. 60, pp. 27-35. Date of Electronic Publication: 2019 Apr 20.
DOI: 10.1016/j.ceb.2019.03.008
Abstrakt: The asymmetric division of adult stem cells into one self-renewing stem cell and one differentiating cell is critical for maintaining homeostasis in many tissues. One paradigmatic model of this division is the Drosophila male and female germline stem cell, which provides two model systems not only sharing common features but also having distinct characteristics for studying asymmetric stem cell division in vivo. This asymmetric division is controlled by a combination of extrinsic signaling molecules and intrinsic factors that are either asymmetrically segregated or regulated differentially following division. In this review, we will discuss recent advances in understanding the molecular and cellular mechanisms guiding this asymmetric outcome, including extrinsic cues, intrinsic factors governing cell fate specification, and cell cycle control.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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