Molluscicidal effectiveness of Luo-Wei, a novel plant-derived molluscicide, against Oncomelania hupensis, Biomphalaria alexandrina and Bulinus truncatus.

Autor: Jia TW; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China.; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China.; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China.; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China.; Communicable Diseases Cluster, World Health Organization Regional Office for Africa (WHO/AFRO), PO Box 06, Brazzaville, Congo., Wang W; Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasites and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, 214064, China., Sun LP; Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasites and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, 214064, China., Lv S; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China.; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China.; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China.; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China.; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China., Yang K; Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasites and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, 214064, China., Zhang NM; Hubei Jinhaichao Science & Technology Co., Ltd, Wuhan, 430206, China., Huang XB; Hubei Provincial Center for Disease Control and Prevention, Wuhan, 430079, China., Liu JB; Hubei Provincial Center for Disease Control and Prevention, Wuhan, 430079, China., Liu HC; Hubei Provincial Center for Disease Control and Prevention, Wuhan, 430079, China., Liu RH; School of Chemistry and Chemical Engineering, Wuhan Textile University, Wuhan, 430200, China., Gawish FA; Department of Medical Malacology, Theodor Bilharz Research Institute (TBRI), Imbaba, Giza, 12411, Egypt., Habib MR; Department of Medical Malacology, Theodor Bilharz Research Institute (TBRI), Imbaba, Giza, 12411, Egypt., El-Emam MA; Department of Medical Malacology, Theodor Bilharz Research Institute (TBRI), Imbaba, Giza, 12411, Egypt., King CH; Center for Global Health and Diseases, Case Western Reserve University, Cleveland, OH, USA. chk@case.edu.; Schistosomiasis Consortium for Operational Research and Evaluation, University of Georgia, Athens, GA, USA. chk@case.edu., Zhou XN; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, 200025, China. xiaonongzhou1962@gmail.com.; Chinese Center for Tropical Diseases Research, Shanghai, 200025, China. xiaonongzhou1962@gmail.com.; WHO Collaborating Centre for Tropical Diseases, Shanghai, 200025, China. xiaonongzhou1962@gmail.com.; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China. xiaonongzhou1962@gmail.com.; Key Laboratory of Parasite and Vector Biology, Ministry of Health, Shanghai, 200025, China. xiaonongzhou1962@gmail.com.
Jazyk: angličtina
Zdroj: Infectious diseases of poverty [Infect Dis Poverty] 2019 Mar 31; Vol. 8 (1), pp. 27. Date of Electronic Publication: 2019 Mar 31.
DOI: 10.1186/s40249-019-0535-7
Abstrakt: Background: Control of snail intermediate hosts has been proved to be a fast and efficient approach for interrupting the transmission of schistosomiasis. Some plant extracts have shown obvious molluscicidal activity, and a new compound Luo-Wei, also named tea-seed distilled saponin (TDS), was developed based on the saponins extracted from Camellia oleifera seeds. We aimed to test the molluscicidal activity of 4% TDS against the intermediate host snails in China and Egypt, and evaluate its environmental safety to non-target organisms.
Methods: In the laboratory, Oncomelania hupensis, Biomphalaria alexandrina and Bulinus truncatus were exposed to 4% TDS, and the median lethal concentration (LC 50 ) was estimated at 24, 48 and 72 h. In the field, snail mortalities were assessed 1, 2, 3 and 7 d post-immersion with 2.5 g/m 3 4% TDS and 1, 3, 7 and 15 d post-spraying with 5 g/m 2 4% TDS. In addition, the acute toxicity of 4% TDS to Japanese quail (Coturnix japonica), zebrafish (Brachydanio rerio) and freshwater shrimp (Macrobrachium nipponense) was assessed by estimations of LC 50 or median lethal dose (LD 50 ).
Results: In the laboratory, the LC 50 values of 4% TDS for O. hupensis were 0.701, 0.371 and 0.33 mg/L at 24, 48 and 72 h, respectively, and 4% TDS showed a 1.975 mg/L [corrected] 24 h LC 50 against B. alexandrina, and a 1.396 mg/L 24 h LC 50 against B. truncatus. Across all study regions, the pooled mortalities of O. hupensis were 72, 86, 94 and 98% at 1, 2, 3 and 7 d, following field immersion of 4% TDS at a dose of 2.5 g/m 3 , and were 69, 77, 85 and 88% at 1, 3, 7 and 15 d, following field spraying at 5 g/m 2 , respectively. 4% TDS had moderate toxicity to Japanese quail (7 d LD 50  > 60 mg/kg) and to shrimp (96 h LC 50  = 6.28 mg/L; 95% CI: 3.53-11.2 mg/L), whereas its toxicity to zebrafish was high (96 h LC 50  = 0.15 mg/L; 95% CI: 0.14-0.17 mg/L).
Conclusions: 4% TDS is active against O. hupensis, B. alexandrina and B. truncatus under laboratory and field conditions, and it may be a candidate molluscicide of plant origin.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje