| Autor: |
Shirshev SV; Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia., Nekrasova IV; Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia. nirina5@mail.ru., Gorbunova OL; Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia., Orlova EG; Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, 614081, Perm, Russia. |
| Abstrakt: |
The effect of estradiol (E 2 ), progesterone (P 4 ), and oncostatin M (OSM) on the differentiation of CD4 + T cells to T regulatory (Treg) lymphocytes and T helpers 17 (Th17) was investigated. The possibility of revision of the T cell receptor in these subpopulations by evaluating the expression of RAG-1 recombinase was also studied. E 2 at concentrations characteristic of pregnancy trimester I, but no P 4 or OSM, increased the Treg level. Combination of sex steroids with OSM increased the percent of CD4 + FOXP3 + cells and enhanced RAG-1 expression in these cells, thus promoting the development of immune tolerance during pregnancy. In the study of Th17, such effect of the hormones and OSM was not detected. |
