White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.

Autor: Alber J; Department of Biomedical and Pharmaceutical Sciences, George & Anne Ryan Institute for Neuroscience, University of Rhode Island, Kingston, RI, USA., Alladi S; Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India., Bae HJ; Cerebrovascular Disease Center, Seoul National University Bundang Hospital, Seongnam, Korea., Barton DA; Department of Psychiatry, University of Melbourne, Melbourne, Australia., Beckett LA; Department of Public Health Sciences, School of Medicine University of California, Davis, CA, USA., Bell JM; Syneos Health, Wilmington, NC, USA., Berman SE; Wisconsin Alzheimer's Disease Research Center, Medical Scientist Training Program, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Biessels GJ; Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus Institute, University Medical Center Utrecht, Utrecht, The Netherlands., Black SE; Department of Medicine, University of Toronto, Sunnybrook Research Institute, Toronto, ON, Canada., Bos I; Department of Psychiatry & Neuropsychology, Alzheimer Centre Limburg, School for Mental Health & Neuroscience, Maastricht University, Maastricht, The Netherlands., Bowman GL; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.; Department of Neurology, Oregon Health & Science University, Portland, OR, USA., Brai E; Neuro-Bio Ltd, Culham Science Centre, Abingdon, UK., Brickman AM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA., Callahan BL; Department of Psychology, University of Calgary & Hotchkiss Brain Institute, Calgary, AB, Canada., Corriveau RA; Department of Psychology, University of Calgary & Hotchkiss Brain Institute, Calgary, AB, Canada., Fossati S; Departments of Neurology and Psychiatry, NYU School of Medicine, New York, NY, USA., Gottesman RF; Division of Cerebrovascular Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Gustafson DR; Section for NeuroEpidemiology, State University of New York - Downstate Medical Center, Brooklyn, NY, USA., Hachinski V; Western University, London Health Sciences Centre, London, ON, Canada., Hayden KM; Department of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Helman AM; University of Kentucky, Sanders-Brown Center on Aging, Lexington, KY, USA., Hughes TM; Department of Internal Medicine - Section of Gerontology and Geriatric Medicine, and Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC, USA., Isaacs JD; St George's University of London and Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK., Jefferson AL; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA., Johnson SC; Department of Medicine-Geriatrics, Institute on Aging, University of Wisconsin-Madison, Madison, WI, USA., Kapasi A; Department of Pathology (Neuropathology), Rush Alzheimer's Disease Center, Chicago, IL, USA., Kern S; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden., Kwon JC; Department of Neurology, Changwon Fatima Hospital, Changwon, Korea., Kukolja J; Department of Neurology and Clinical Neurophysiology, Helios University Hospital Wuppertal, Wuppertal, Germany., Lee A; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA., Lockhart SN; Department of Internal Medicine - Section of Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Murray A; Berman Center for Outcomes and Clinical Research, 20298 Minneapolis Medical Research Foundation, Minneapolis, MN, USA., Osborn KE; Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA., Power MC; Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, Washington, DC, USA., Price BR; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Rhodius-Meester HFM; Alzheimer Center, Department of Neurology, VU University Medical Centre, Amsterdam Neuroscience, Amsterdam, The Netherlands., Rondeau JA; Montclair Memory Clinic, Montclair, NJ, USA., Rosen AC; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA., Rosene DL; Anatomy & Neurobiology, Boston University School of Medicine, Boston, MA, USA., Schneider JA; Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA., Scholtzova H; Department of Neurology, NYU School of Medicine, New York, NY, USA., Shaaban CE; Department of Epidemiology, Graduate School of Public Health & Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA., Silva NCBS; School of Kinesiology, Western Centre for Public Health & Family Medicine, London, ON, Canada., Snyder HM; Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, IL, USA., Swardfager W; Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada., Troen AM; Institute of Biochemistry Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture Food and Environment, The Hebrew University of Jerusalem, Jerusalem, Israel., van Veluw SJ; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Vemuri P; Department of Radiology, Mayo Clinic Rochester, Rochester, MN, USA., Wallin A; Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Wellington C; Department of Pathology and Laboratory Medicine, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada., Wilcock DM; Sanders-Brown Center on Aging, Department of Physiology, University of Kentucky, Lexington, KY, USA., Xie SX; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA., Hainsworth AH; Molecular & Clinical Sciences Research Institute, St George's University of London and Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2019 Apr 09; Vol. 5, pp. 107-117. Date of Electronic Publication: 2019 Apr 09 (Print Publication: 2019).
DOI: 10.1016/j.trci.2019.02.001
Abstrakt: White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.
Databáze: MEDLINE