Integration of a Personalized Molecular Targeted Therapy into the Multimodal Treatment of Refractory Childhood Embryonal Tumor with Multilayered Rosettes (ETMR).

Autor: Hartman LLR; Texas Tech University Health Sciences Center at El Paso, El Paso, Texas, USA.; El Paso Children's Hospital, El Paso, Texas, USA., Oaxaca DM; Texas Tech University Health Sciences Center at El Paso, El Paso, Texas, USA.; Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA., Carcamo B; Texas Tech University Health Sciences Center at El Paso, El Paso, Texas, USA.; El Paso Children's Hospital, El Paso, Texas, USA., Wilson HL; Texas Tech University Health Sciences Center at El Paso, El Paso, Texas, USA.; El Paso Children's Hospital, El Paso, Texas, USA., Ross JA; Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA., Robles-Escajeda E; Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA., Kirken RA; Department of Biological Sciences, The University of Texas at El Paso, El Paso, Texas, USA.
Jazyk: angličtina
Zdroj: Case reports in oncology [Case Rep Oncol] 2019 Feb 28; Vol. 12 (1), pp. 211-217. Date of Electronic Publication: 2019 Feb 28 (Print Publication: 2019).
DOI: 10.1159/000497380
Abstrakt: Embryonal tumor with multilayered rosettes (ETMR) are rare pediatric brain tumors with increased malignant potential. Despite the advances in multimodal treatment schemes the overall 5-year event free survival rates for ETMR are not favorable. Further, therapeutic regimes are limited to a case by case basis due to the limited amount of literature and guidelines available for treating childhood ETMR. We report one patient with refractory ETMR who was successfully treated by implementing a molecular profiling approach which identified the tyrosine kinase inhibitor dasatinib as a viable therapy. Our results suggest that utilizing this precision medicine approach might prove useful in treating patients with refractory ETMR.
Databáze: MEDLINE
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