| Autor: |
Khien VV; Departments of GI Endoscopy, 108 Central Hospital, Hanoi, Vietnam., Thang DM; Departments of GI Endoscopy, 108 Central Hospital, Hanoi, Vietnam., Hai TM; Departments of Molecular Biology, 108 Central Hospital, Hanoi, Vietnam.; University of Science and Technology of Hanoi, Hanoi, Vietnam., Duat NQ; Department of Gastroenterology, 103 Hospital, Hanoi, Vietnam., Khanh PH; Department of Gastroenterology, 103 Hospital, Hanoi, Vietnam., Ha DT; Department of Gastroenterology, National Children Hospital, Hanoi, Vietnam., Binh TT; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Vietnam., Dung HDQ; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Vietnam., Trang TTH; Departments of Molecular Biology, 108 Central Hospital, Hanoi, Vietnam., Yamaoka Y; Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Oita, Japan. |
| Abstrakt: |
Antibiotic resistance is the most important factor leading to the failure of eradication regimens. This review focuses on the prevalence of Helicobacter pylori primary and secondary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug in Vietnam. We searched the PubMed, EMBASE, Vietnamese National Knowledge Infrastructure, and Vietnamese Biomedical databases from January 2000 to December 2016. The search terms included the following: H. pylori infection, antibiotic (including clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug) resistance in Vietnam. The data were summarized in an extraction table and analyzed manually. Finally, Excel 2007 software was used to create charts. Ten studies (three studies in English and seven in Vietnamese) were included in this review. A total of 308, 412, 523, 408, 399, and 268 H. pylori strains were included in this review to evaluate the prevalence of H. pylori primary resistance to amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance, respectively. Overall, the primary resistance rates of amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance were 15.0%, 34.1%, 69.4%, 27.9%, 17.9% and 48.8%, respectively. Secondary resistance rates of amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance were 9.5%, 74.9%, 61.5%, 45.7%, 23.5% and 62.3%, respectively. In Vietnam, primary and secondary resistance to H. pylori is increasing over time and affects the effectiveness of H. pylori eradication. |
