Lactobacillus plantarum HY7714 Restores TNF-α Induced Defects on Tight Junctions.
| Autor: | Nam B; R&BD Center, Korea Yakult Co., Ltd., Gyeonggi 17086, Korea., Kim SA; R&BD Center, Korea Yakult Co., Ltd., Gyeonggi 17086, Korea., Nam W; R&BD Center, Korea Yakult Co., Ltd., Gyeonggi 17086, Korea., Jeung WH; R&BD Center, Korea Yakult Co., Ltd., Gyeonggi 17086, Korea., Park SD; R&BD Center, Korea Yakult Co., Ltd., Gyeonggi 17086, Korea., Lee JL; R&BD Center, Korea Yakult Co., Ltd., Gyeonggi 17086, Korea.; College of Veterinary Medicine, Konkuk University, Seoul, Korea., Sim JH; R&BD Center, Korea Yakult Co., Ltd., Gyeonggi 17086, Korea., Jang SS; R&BD Center, Korea Yakult Co., Ltd., Gyeonggi 17086, Korea. |
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| Jazyk: | angličtina |
| Zdroj: | Preventive nutrition and food science [Prev Nutr Food Sci] 2019 Mar; Vol. 24 (1), pp. 64-69. Date of Electronic Publication: 2019 Mar 31. |
| DOI: | 10.3746/pnf.2019.24.1.64 |
| Abstrakt: | In addition to intestinal balance, probiotics are known to have beneficial effects on skin inflammation, metabolic diseases, and emotions. Previously, we have reported the skin anti-aging effects of Lactobacillus plantarum HY7714 (HY7714) in a clinical trial. To prove the protective skin effects of HY7714 through the intestinal tight junction (TJ), we investigated the effects of HY7714 on the intestines through tumor necrosis factor (TNF)-α induced TJ defects in Caco-2 cells. Specifically, 24 h treatment with HY7714 restored the decreased expression of zonula occludens-1, occludin, and claudin-1 compared to the TNF-α-treated groups ( P <0.05). It also attenuated the level of pro-inflammatory cytokines interleukin-6, 8, and 1β. Further, increases in the mRNA levels of Elk-1, nuclear factor-κB, and myosin light chain kinase expression induced by TNF-α were recovered by HY7714. These findings imply that HY7714 improves intestinal barrier integrity and is a potential therapeutic agent for dysfunctions derived from TJ defects. Competing Interests: AUTHOR DISCLOSURE STATEMENT The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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