A Multicenter, Randomized, Equivalence Trial of a New Recombinant Human Chorionic Gonadotropin Preparation versus Ovitrelle ® for Ovulation in Women Undergoing Intrauterine Insemination Following Ovarian Stimulation.

Autor: Majumdar A; Department of Obstetrics and Gynaecology, Sir Ganga Ram Hospital, New Delhi, India., Sachan R; Department of Obstetrics and Gynaecology, King George's Medical University, Lucknow, Uttar Pradesh, India., Nandanwar YS; Department of Obstetrics and Gynaecology, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, Maharashtra, India., Mayekar RV; Department of Obstetrics and Gynaecology, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, Maharashtra, India., Soni N; Department of Obstetrics and Gynaecology, Choithram Hospital and Research Centre, Indore, Madhya Pradesh, India., Banker MR; Nova IVI Fertility, Ahmedabad, Gujarat, India., Vaidya RS; Department of Obstetrics and Gynaecology, Nowrosjee Wadia Maternity Hospital, Mumbai, Maharashtra, India., Arora M; Department of Obstetrics and Gynaecology, Batra Hospital and Medical Research Centre, New Delhi, India., Godbole GP; Department of Obstetrics and Gynaecology, Deenanath Mangeshkar Hospital and Research Centre, Pune, Maharashtra, India., Daftary GV; Research and Development, Bharat Serums and Vaccines Limited, Navi Mumbai, Maharashtra, India., Divekar GH; Department of Clinical Research and Pharmacovigilance, Bharat Serums and Vaccines Limited, Navi Mumbai, Maharashtra, India., John J; Department of Clinical Research and Pharmacovigilance, Bharat Serums and Vaccines Limited, Navi Mumbai, Maharashtra, India.
Jazyk: angličtina
Zdroj: Journal of human reproductive sciences [J Hum Reprod Sci] 2019 Jan-Mar; Vol. 12 (1), pp. 53-58.
DOI: 10.4103/jhrs.JHRS_101_18
Abstrakt: Context: A new indigenous recombinant human chorionic gonadotropin (r-hCG) has been developed in India with a comparable pharmacological profile to that of Ovitrelle ® (Merck Serono).
Aims: This study aims to compare the efficacy and safety of the new r-hCG with that of Ovitrelle for induction of ovulation in women undergoing intrauterine insemination (IUI).
Settings and Design: Randomized (2:1), multicenter, open-label, equivalence clinical trial conducted in India.
Subjects and Methods: A total of 217 women, aged 20-37 years, undergoing IUI were administered the new r-hCG (test) 250 mcg or Ovitrelle 250 mcg (comparator) after ovarian stimulation with gonadotropins. The ovulation rate was compared as the primary outcome. In addition, pregnancy rates, incidence of adverse events (AEs), and development of immunogenicity were assessed. Statistical Analysis Used: The ovulation and pregnancy rates were compared using Chi-squared test with statistical significance at P < 0.05.
Results: With 144 women in the test group and 73 in the comparator group, the ovulation rate (85.4% vs. 78.1%; P = 0.17) and pregnancy rate (serum β hCG test) (11.8% vs. 12.3%; P = 0.91) were similar in both groups. A total of 15 AEs were reported (11 in the test r-hCG group and 4 in the comparator group) in 11 women; none of these were serious, and all were judged to be unrelated to the study drug. No subject developed immunogenic reaction to the test drug.
Conclusions: The new preparation of r-hCG was equivalent to the conventional preparation of r-HCG in the induction of ovulation in patients undergoing IUI.
Competing Interests: Dr. Gautam Daftary is a Managing Director of Bharat Serums and Vaccines Limited. Dr. Ganesh Divekar and Dr. James John are full-time paid employees of Bharat Serums and Vaccines Limited. Bharat Serums and Vaccines funded the entire study.
Databáze: MEDLINE
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