High-symmetry protein assemblies: patterns and emerging applications.

Autor: Cannon KA; UCLA Department of Chemistry and Biochemistry, United States; UCLA-DOE Institute for Genomics and Proteomics, United States., Ochoa JM; UCLA Department of Chemistry and Biochemistry, United States; UCLA Molecular Biology Institute, United States., Yeates TO; UCLA Department of Chemistry and Biochemistry, United States; UCLA-DOE Institute for Genomics and Proteomics, United States; UCLA Molecular Biology Institute, United States. Electronic address: yeates@mbi.ucla.edu.
Jazyk: angličtina
Zdroj: Current opinion in structural biology [Curr Opin Struct Biol] 2019 Apr; Vol. 55, pp. 77-84. Date of Electronic Publication: 2019 Apr 18.
DOI: 10.1016/j.sbi.2019.03.008
Abstrakt: The accelerated elucidation of three-dimensional structures of protein complexes, both natural and designed, is providing new examples of large supramolecular assemblies with intriguing shapes. Those with high symmetry - based on the geometries of the Platonic solids - are particularly notable as their innately closed forms create interior spaces with varying degrees of enclosure. We survey known protein assemblies of this type and discuss their geometric features. The results bear on issues of protein function and evolution, while also guiding novel bioengineering applications. Recent successes using high-symmetry protein assemblies for applications in interior encapsulation and exterior display are highlighted.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: