Cytokine Profiles Associated With Angiotensin II Type 1 Receptor Antibodies.

Autor:	Pearl MH; Department of Pediatrics, Division of Pediatric Nephrology, University of California, Los Angeles, Los Angeles, California, USA., Grotts J; Department of Medicine Statistics Core, University of California, Los Angeles, Los Angeles, California, USA., Rossetti M; Department of Pathology and Laboratory Medicine University of California, Los Angeles, Los Angeles, California, USA., Zhang Q; Department of Pathology and Laboratory Medicine University of California, Los Angeles, Los Angeles, California, USA., Gjertson DW; Department of Pathology and Laboratory Medicine University of California, Los Angeles, Los Angeles, California, USA., Weng P; Department of Pediatrics, Division of Pediatric Nephrology, University of California, Los Angeles, Los Angeles, California, USA., Elashoff D; Department of Medicine Statistics Core, University of California, Los Angeles, Los Angeles, California, USA., Reed EF; Department of Pathology and Laboratory Medicine University of California, Los Angeles, Los Angeles, California, USA., Tsai Chambers E; Department of Pediatrics, Division of Pediatric Nephrology, Duke University, Durham, North Carolina, USA.
Jazyk:	angličtina
Zdroj:	Kidney international reports [Kidney Int Rep] 2018 Dec 21; Vol. 4 (4), pp. 541-550. Date of Electronic Publication: 2018 Dec 21 (Print Publication: 2019).
DOI:	10.1016/j.ekir.2018.12.011
Abstrakt:	Introduction: Angiotensin II type 1 receptor antibody (AT1R-Ab), is a non-human leukocyte antigen (HLA) antibody implicated in poor renal allograft outcomes, although its actions may be mediated through a different pathway than HLA donor-specific antibodies (DSAs). Our aim was to examine serum cytokine profiles associated with AT1R-Ab and distinguish them from those associated with HLA DSA in serially collected blood samples from a cohort of pediatric renal transplant recipients. Methods: Blood samples from 65 pediatric renal transplant recipients drawn during the first 3 months posttransplant, at 6, 12, and 24 months posttransplant, and during suspected episodes of kidney transplant rejection were tested for AT1R-Ab, HLA DSA, and a panel of 6 cytokines (tumor necrosis factor [TNF]-α, interferon [IFN]-γ, interleukin [IL]-8, IL-1β, IL-6, and IL-17). Associations between antibodies and cytokines were evaluated. Results: AT1R-Ab, but not HLA DSA, was associated with elevations in TNF-α, IFN-γ, IL-8, IL-1β, IL-6, and IL-17. This relationship remained significant even after controlling for relevant clinical factors and was consistent across all time points. In contrast to HLA DSA, AT1R-Ab was associated with elevations in vascular inflammatory cytokines in the first 2 years posttransplant. Conclusions: This profile of vascular cytokines may be informative for clinical monitoring and designing future studies to delineate the distinct pathophysiology of AT1R-Ab-mediated allograft injury in kidney transplantation.
Databáze:	MEDLINE
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