| Autor: |
Jones H, Fordice MW, Greenwald RB, Hannah J, Jacobs A, Ruyle WV, Walford GL, Shen TY |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1978 Nov; Vol. 21 (11), pp. 1100-4. |
| DOI: |
10.1021/jm00209a002 |
| Abstrakt: |
We have made a series of 4- and 5-aryl- and 4- and 5-heteroarylsalicylic acid derivatives with the objective of reducing gastric irritation and increasing potency. Here we describe a series of 4- and 5-heterocyclic salicylic acids and their antiinflammatory-analgesic potencies measured in comparison to aspirin. An improvement of the therapeutic index over aspirin of 100 was achieved; however, the heterocyclic salicylic acids lacked antipyretic activity. Some physicochemical parameters which may bear on the antiinflammatory activity of these compounds are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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