| Autor: |
Ribeiro MGM; Universidade Federal de Sergipe - UFS, Department of Morphology, Aracaju, SE, Brazil., Marcolino LD; Universidade Estadual Paulista - Unesp, Botucatu Medical School, Department of Pathology, Botucatu, SP, Brazil., Ramos BRA; Universidade Estadual Paulista - Unesp, Botucatu Medical School, Department of Pathology, Botucatu, SP, Brazil., Trento CL; Universidade Federal de Sergipe - UFS, Department of Dentistry, Aracaju, SE, Brazil., Araujo KCGM; Universidade Federal de Sergipe - UFS, Department of Morphology, Aracaju, SE, Brazil., Silva JRS; Universidade Federal de Sergipe - UFS, Department of Statistics and Actuarial Sciences, Aracaju, SE, Brazil., Jain S; Universidade Federal de Sergipe - UFS, Department of Morphology, Aracaju, SE, Brazil., Gurgel RQ; Universidade Federal de Sergipe - UFS, Department of Medicine, Aracaju, SE, Brazil., Silva MG; Universidade Estadual Paulista - Unesp, Botucatu Medical School, Department of Pathology, Botucatu, SP, Brazil., Dolabella SS; Universidade Federal de Sergipe - UFS, Department of Morphology, Aracaju, SE, Brazil. |
| Abstrakt: |
Variable rates of HPV infection have been reported in healthy oral mucosa worldwide. The main objective of this study was to detect and genotype HPV infection in users and nonusers of drugs with clinically healthy mucosa from the Northeast Brazil. Samples from 105 patients were amplified using the primers MY09/MY11 and GP5+/GP6+, and genotyping was performed by multiplex-PCR for HPV-6/11, 16 and 18. A total of 81.9% samples were positive. Among drug users, 84.5% presented the virus and 20.4% showed multiple infections. Among non-drug users, 78.7% were positive and 13.5% had multiple infections. Limited information is available on oral HPV in Brazilian population, especially for drug users, and our results showed higher HPV infection rates in both users and nonusers of drugs. More studies and researches focused on drug users including factors like sexual behavior, nutrition and cultural habits are necessary to enhance the comprehension of this relationship, and develop preventive strategies. |
