| Autor: |
Nicol GE; 1Healthy Mind Lab, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri., Kolko R; 2Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, Pennsylvania., Lenze EJ; 1Healthy Mind Lab, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri., Yingling MD; 1Healthy Mind Lab, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri., Miller JP; 1Healthy Mind Lab, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.; 3Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri., Ricchio AR; 1Healthy Mind Lab, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri., Schweiger JA; 1Healthy Mind Lab, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri., Findling RL; 4Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland., Wilfley D; 1Healthy Mind Lab, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.; 5Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.; 6Department of Medicine, Washington University School of Medicine, St. Louis, Missouri., Newcomer JW; 1Healthy Mind Lab, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri.; 7Thriving Mind South Florida Behavioral Health Network, Miami, Florida. |
| Abstrakt: |
Objectives: The purpose of this pilot study was to evaluate changes in adiposity, carotid intima media thickness (CIMT), and hepatic fat content measured via magnetic resonance imaging-estimated hepatic proton density fat fraction (PDFF) in antipsychotic (AP)-treated youth versus nonpsychiatric (NP) participants during participation in a 16-week behavioral weight loss (BWL) intervention. Subjects/Methods: Overweight/obese AP-treated youth ( n = 26) were randomized 2:1 to weekly treatment versus recommended care (RC) over 16 weeks. NP controls ( n = 21) were assigned to weekly treatment. Dual-energy X-ray absorptiometry (DEXA)-measured adiposity, CIMT, and PDFF were measured at baseline and 16 weeks. Analyses assessed group differences in the effect of BWL on adiposity, CIMT, and PDFF. Results: BWL was well tolerated in both AP-treated and NP groups. DEXA-measured fat decreased significantly in the NP group ( F [1,16] = 11.81, p = 0.003), with modest improvements in adiposity and hepatic fat in the AP-treated group, while an increase in adiposity was observed in the RC group. Significant differences in endpoint DEXA total fat ( F [2,34] = 4.81, p = 0.01) and PDFF ( F [2,30] = 3.60, p = 0.04) occurred across treatment groups, explained by larger improvements in NP versus RC youth in DEXA total fat ( p = 0.03) and PDFF ( p = 0.04). Conclusions: Intensive, family-based BWL treatment can improve whole-body adiposity and liver fat in obese youth, with decreases or attenuation of additional fat gain observed in AP-treated youth. |
