Three-Component GaHal 3 -Promoted Reactions of Substituted Methylidenemalonates and Donor-Acceptor Cyclopropanes with Propargyl Halides: Cascade Diastereoselective Construction of Five-Membered Lactones.
Autor: | Denisov DA; N. D. Zelinsky Institute of Organic Chemistry , Russian Academy of Sciences , 47 Leninsky prosp. , 119991 Moscow , Russian Federation., Borisov DD; N. D. Zelinsky Institute of Organic Chemistry , Russian Academy of Sciences , 47 Leninsky prosp. , 119991 Moscow , Russian Federation., Korolev VA; N. D. Zelinsky Institute of Organic Chemistry , Russian Academy of Sciences , 47 Leninsky prosp. , 119991 Moscow , Russian Federation., Novikov RA; N. D. Zelinsky Institute of Organic Chemistry , Russian Academy of Sciences , 47 Leninsky prosp. , 119991 Moscow , Russian Federation., Tomilov YV; N. D. Zelinsky Institute of Organic Chemistry , Russian Academy of Sciences , 47 Leninsky prosp. , 119991 Moscow , Russian Federation. |
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Jazyk: | angličtina |
Zdroj: | The Journal of organic chemistry [J Org Chem] 2019 May 17; Vol. 84 (10), pp. 6174-6182. Date of Electronic Publication: 2019 Apr 30. |
DOI: | 10.1021/acs.joc.9b00354 |
Abstrakt: | A new cascade three-component process for high trans,trans-diastereoselective assembly of five-membered (1-halovinyl)lactones has been developed. The process is based on reactions of substituted methylidenemalonates and cyclopropanedicarboxylates with 3-haloprop-1-ynes in the presence of GaHal |
Databáze: | MEDLINE |
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