| Autor: |
da Silva YC; Department of Chemistry, Amazonas Federal University, Manaus, AM, Brazil., Silva EMS; Department of Chemistry, Amazonas Federal University, Manaus, AM, Brazil., Fernandes NS; Department of Chemistry, Amazonas Federal University, Manaus, AM, Brazil.; Department of Basic Health Sciences, Maringá State University, Maringá, PR, Brazil., Lopes NL; Department of Chemistry, Amazonas Federal University, Manaus, AM, Brazil., Orlandi PP; Oswaldo Cruz Foundation, Leônidas and Maria Deane Institute, Manaus, AM, Brazil., Nakamura CV; Department of Basic Health Sciences, Maringá State University, Maringá, PR, Brazil., Costa EV; Department of Chemistry, Amazonas Federal University, Manaus, AM, Brazil., da Veiga Júnior VF; Department of Chemistry, Amazonas Federal University, Manaus, AM, Brazil.; Chemical Engineering Section, Military Institute of Engineering, Rio de Janeiro, RJ, Brazil. |
| Abstrakt: |
Extracts and six isolated substances from Aniba ( Lauraceae ) Amazonian species A. parviflora , A. panurensis and A. rosaeodora were analysed in vitro to their antibacterial, antiparasitic and antiplasmodial activities. NMR and MS experiments led to the identification of three styrylpyrones (5,6-dihydrokawain [I], 4-methoxy-11,12-methylenedioxy-6- trans -styryl-pyran-2-one [II] and rel -(6R,7S,8S,5'S)-4'-methoxy-8-(11,12-dimethoxyphenyl-7-[6-(4-methoxy-2-pyranyl)]-6-( E )-styryl-1'-oxabicyclo[4,2,0]oct-4'-en-2'-one [III]), a pyridine alkaloid (anibine [IV]) and two kavalactones (tetrahydroyangonin [V] and dihydromethysticin [VI]). The best antibacterial result was observed at the hexane fraction of A. panurensis (MIC 7.8 μg/mL against the three bacteria). Equal MIC were observed by the extract and dichloromethane fraction of A. panurensis against S. simulans and S. aureus ; and 15.62 μg/mL against MRSA. Similarly, only A. panurensis extracts showed in vitro activities against Tripanossoma cruzi and Leishmania amazonensis parasites. In Plasmodium falciparum assay, 5,6-dihydrokawain was considered an active antimalarial (14.03 μM), and substances II (132.94 μM) and III (41.84 μM) presented moderate activities. |
