| Autor: |
Hu J; Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University Qujing 655011,China., Lyu T; Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University Qujing 655011,China., Cai J; Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University Qujing 655011,China., Gao X; Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University Qujing 655011,China., Zhang LF; Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University Qujing 655011,China., Jing NH; Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University Qujing 655011,China., Peng TF; Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University Qujing 655011,China., Shi JY; Institute of Characteristic Medicinal Resource of Ethnic Minorities,Qujing Normal University Qujing 655011,China., Hao SH; Nuclear Medicine Department,General Hospital of Shenyang Military Region Shenyang 110016,China. |
| Jazyk: |
čínština |
| Zdroj: |
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2019 Feb; Vol. 44 (4), pp. 717-722. |
| DOI: |
10.19540/j.cnki.cjcmm.20180808.001 |
| Abstrakt: |
Eight C_(19)-diterpenoid alkaloids( 1-8) were isolated from the ethyl acetate soluble fraction of 95% ethanol extract of the ground roots of Aconitum austroyunnanense through various column chromatographies on silica gel,ODS,Sephadex LH-20 and MCI gel.Their structures were elucidated as 14α-benzoyloxy-13β,15α-dihydroxy-1α,6α,8β,16β,18-pentamethoxy-19-oxoaconitan( 1),N-deethylaconitine( 2),spicatine B( 3),leucanthumsine A( 4),acofamine B( 5),macrorhynine B( 6),aconitilearine( 7),and ambiguine( 8) based on their chemical and physicochemical properties and spectroscopic data. Compound 1 was a new compound and alkaloids 2-8 were isolated from this plant for the first time. Some isolated alkaloids were tested in vitro for cytotoxic potential by employing the MTT method. As a result,alkaloid 1 exhibited weak cytotoxic activity against three tested tumor cell lines( A-549,He La,and Hep G2) with IC_(50) values less than 20 μmol·L~(-1). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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