| Autor: |
Rodriguez-Leal D; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Inari Agriculture, Cambridge, MA, USA., Xu C; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China., Kwon CT; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Soyars C; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Demesa-Arevalo E; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Man J; Biology Department, University of Massachusetts Amherst, Amherst, MA, USA., Liu L; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Lemmon ZH; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Inari Agriculture, Cambridge, MA, USA., Jones DS; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Van Eck J; Boyce Thompson Institute for Plant Science, Ithaca, NY, USA.; Plant Breeding and Genetics Section, School of Integrative Plant Science, Cornell University, Ithaca, NY, USA., Jackson DP; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. jacksond@cshl.edu., Bartlett ME; Biology Department, University of Massachusetts Amherst, Amherst, MA, USA. mbartlett@bio.umass.edu., Nimchuk ZL; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. zackn@email.unc.edu., Lippman ZB; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. lippman@cshl.edu.; Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. lippman@cshl.edu. |
| Abstrakt: |
Precise control of plant stem cell proliferation is necessary for the continuous and reproducible development of plant organs 1,2 . The peptide ligand CLAVATA3 (CLV3) and its receptor protein kinase CLAVATA1 (CLV1) maintain stem cell homeostasis within a deeply conserved negative feedback circuit 1,2 . In Arabidopsis, CLV1 paralogs also contribute to homeostasis, by compensating for the loss of CLV1 through transcriptional upregulation 3 . Here, we show that compensation 4,5 operates in diverse lineages for both ligands and receptors, but while the core CLV signaling module is conserved, compensation mechanisms have diversified. Transcriptional compensation between ligand paralogs operates in tomato, facilitated by an ancient gene duplication that impacted the domestication of fruit size. In contrast, we found little evidence for transcriptional compensation between ligands in Arabidopsis and maize, and receptor compensation differs between tomato and Arabidopsis. Our findings show that compensation among ligand and receptor paralogs is critical for stem cell homeostasis, but that diverse genetic mechanisms buffer conserved developmental programs. |
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