Process-based framework for precise neuromodulation.

Autor: Lubianiker N; Sagol Brain Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel.; School of Psychological Sciences, Gershon H. Gordon Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel., Goldway N; Sagol Brain Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Fruchtman-Steinbok T; Sagol Brain Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel.; School of Psychological Sciences, Gershon H. Gordon Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel., Paret C; Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health Mannheim, Medical Faculty Mannheim / Heidelberg University, Mannheim, Germany., Keynan JN; Sagol Brain Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel.; School of Psychological Sciences, Gershon H. Gordon Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel., Singer N; Sagol Brain Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel.; School of Psychological Sciences, Gershon H. Gordon Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel., Cohen A; Sagol Brain Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel.; School of Psychological Sciences, Gershon H. Gordon Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel., Kadosh KC; Department of Experimental Psychology, University of Oxford, Oxford, UK.; School of Psychology, University of Surrey, Guildford, UK., Linden DEJ; MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK.; School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands., Hendler T; Sagol Brain Institute, Tel-Aviv Medical Center, Tel-Aviv, Israel. talma@tlvmc.gov.il.; School of Psychological Sciences, Gershon H. Gordon Faculty of Social Sciences, Tel Aviv University, Tel Aviv, Israel. talma@tlvmc.gov.il.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel. talma@tlvmc.gov.il.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. talma@tlvmc.gov.il.
Jazyk: angličtina
Zdroj: Nature human behaviour [Nat Hum Behav] 2019 May; Vol. 3 (5), pp. 436-445. Date of Electronic Publication: 2019 Apr 15.
DOI: 10.1038/s41562-019-0573-y
Abstrakt: Functional MRI neurofeedback (NF) allows humans to self-modulate neural patterns in specific brain areas. This technique is regarded as a promising tool to translate neuroscientific knowledge into brain-guided psychiatric interventions. However, its clinical implementation is restricted by unstandardized methodological practices, by clinical definitions that are poorly grounded in neurobiology, and by lack of a unifying framework that dictates experimental choices. Here we put forward a new framework, termed 'process-based NF', which endorses a process-oriented characterization of mental dysfunctions to form precise and effective psychiatric treatments. This framework relies on targeting specific dysfunctional mental processes by modifying their underlying neural mechanisms and on applying process-specific contextual feedback interfaces. Finally, process-based NF offers designs and a control condition that address the methodological shortcomings of current approaches, thus paving the way for a precise and personalized neuromodulation.
Databáze: MEDLINE
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