Switching to Aflibercept in Diabetic Macular Edema after Unsatisfactory Response to Other Anti-vascular Endothelial Growth Factor Drugs.

Autor:	Ibrahim WS; Department of Ophthalmology, Assiut University, Assiut, Egypt., Eldaly ZH; Department of Ophthalmology, Assiut University, Assiut, Egypt. dr_ziadeldaly@aun.edu.eg., Saleh MG; Department of Ophthalmology, Assiut University, Assiut, Egypt., Rateb MF; Department of Ophthalmology, Assiut University, Assiut, Egypt., Aldoghaimy AH; Department of Ophthalmology, South Valley University, Qena, Egypt.
Jazyk:	angličtina
Zdroj:	Korean journal of ophthalmology : KJO [Korean J Ophthalmol] 2019 Apr; Vol. 33 (2), pp. 122-130.
DOI:	10.3341/kjo.2018.0037
Abstrakt:	Purpose: To evaluate the efficacy of switching to aflibercept in diabetic macular edema (DME) with suboptimal response to previous anti-vascular endothelial growth factor (anti-VEGF) injections. Methods: A prospective interventional case series study recruited patients from a single center diagnosed with DME with suboptimal response to anti-VEGF injections. Three consecutive monthly injections of aflibercept were performed. The primary outcome measure was mean change in visual acuity after switching to aflibercept. Results: Forty-two patients (42 eyes) were included. Baseline logarithm of the minimum angle of resolution (logMAR) visual acuity was 0.87 ± 0.23 and improved significantly to 0.62 ± 0.29, 0.56 ± 0.34, and 0.46 ± 0.35 at 1, 2, and 3 months, respectively, after the first injection. Mean baseline retinal thickness was 451.57 ± 107.09 μm and decreased significantly at 1, 2, and 3 months after switching to aflibercept (346.52 ± 79.03, 328.24 ± 81.98, and 313.71 ± 85.79 μm, respectively). Both visual improvement and mean change in retinal thickness were significant in patients with pre-aflibercept best-corrected visual acuity less than 1.0 logMAR but were not significant in patients with best-corrected visual acuity more than 1.0 logMAR. Conclusions: Switching to aflibercept in DME patients with an unsatisfactory response to previous anti-VEGF injections provided acceptable short-term visual and retinal architectural improvement. Competing Interests: No potential conflict of interest relevant to this article was reported. (© 2019 The Korean Ophthalmological Society.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu