Dose-response evaluation of a copaiba-containing varnish against streptococcus mutans in vivo.

Autor:	Valadas LAR; Postgraduate Program in Drug Development, School of Pharmacy, Federal University of Ceará, Brazil., Gurgel MF; Department of Clinical Dentistry, School of Dentistry-Campus Sobral, Federal University of Ceará, Brazil., Mororó JM; Department of Clinical Dentistry, School of Dentistry-Campus Sobral, Federal University of Ceará, Brazil., Fonseca SGDC; Postgraduate Program in Drug Development, School of Pharmacy, Federal University of Ceará, Brazil., Fonteles CSR; Postgraduate Program in Dentistry, Department of Clinical Dentistry, School of Dentistry, Federal University of Ceará, Brazil., de Carvalho CBM; Department of Pathology and Legal Medicine, School of Medicine, Federal University of Ceará, Brazil., Fechine FV; Clinical Pharmacology Unit, Department of Pharmacology, School of Medicine, Federal University of Ceará, Brazil., Rodrigues Neto EM; Postgraduate Program in Drug Development, School of Pharmacy, Federal University of Ceará, Brazil., de França Fonteles MM; Postgraduate Program in Drug Development, School of Pharmacy, Federal University of Ceará, Brazil., Chagas FO; Department of Clinical Dentistry, School of Dentistry-Campus Sobral, Federal University of Ceará, Brazil., Lobo PLD; Postgraduate Program in Drug Development, School of Pharmacy, Federal University of Ceará, Brazil.; Department of Clinical Dentistry, School of Dentistry-Campus Sobral, Federal University of Ceará, Brazil., Bandeira MAM; Postgraduate Program in Drug Development, School of Pharmacy, Federal University of Ceará, Brazil.
Jazyk:	angličtina
Zdroj:	Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2019 Mar; Vol. 27 (3), pp. 363-367. Date of Electronic Publication: 2018 Dec 15.
DOI:	10.1016/j.jsps.2018.12.004
Abstrakt:	Introduction: Dental caries is the most prevalent disease in humans and its incidence is particularly high during childhood. The use of medicinal plants is a common practice in Brazil. Objective: To evaluate the optimal antimicrobial concentration of Copaifera langsdorffii (copaiba) oil-resin, in the form of dental varnish, against Streptococcus mutans ( S. mutans ) in children. Methods: Twenty-four children, caries-free, aged until 6 years old, were selected to participate in this study. The varnish was applied to the occlusal surfaces of all deciduous molars. The antimicrobial activity was analyzed in saliva, whose collection was conducted in two phases: before applying the copaiba varnish and after use to verify the instantaneous effectiveness of Copaifera langsdorffii dental varnish in the reduction of S. mutans . The microbiological analysis was repeated twice, establishing dilutions of 1:10 mL and 1:100 mL. Results: Comparisons between different times within the same dilution were carried out by repeated measures analysis of variance (ANOVA) associated with Tukey's multiple comparisons test. Comparisons of conditions prior to and after treatment were performed using the t test for paired samples and it indicated that the 1% formulation promoted a more significant decrease in the number of S. mutans colonies (p = 0,0026). Conclusion: Copaiba oil-resin, in the form of dental varnish, has antimicrobial activity against S. mutans in all the concentrations studied. Further studies to identify the long-term activity and anticaries effect of this varnish are required to establish its use in caries prevention.
Databáze:	MEDLINE
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