| Autor: |
Dos Santos Lima GZ; Escola de Ciências e Tecnologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. gzampier@ect.ufrn.br.; Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil. gzampier@ect.ufrn.br.; Keck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, MA, USA. gzampier@ect.ufrn.br., Lobao-Soares B; Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Corso G; Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Belchior H; Faculdade de Ciências da Saúde do Trairí, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Lopes SR; Departamento de Física, Universidade Federal do Paraná, Curitiba, PR, Brazil., de Lima Prado T; Instituto de Engenharia, Ciência e Tecnologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Janaúba, MG, Brazil., Nascimento G; Departamento de Engenharia Biomédica, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., França AC; Instituto do Cérebro, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Fontenele-Araújo J; Departamento de Fisiologia e Comportamento, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil., Ivanov PC; Keck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, MA, USA. plamen@physics.bu.edu.; Division of Sleep Medicine and Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. plamen@physics.bu.edu. |
| Abstrakt: |
Sleep plays a crucial role in the regulation of body homeostasis and rhythmicity in mammals. Recently, a specific component of the sleep structure has been proposed as part of its homeostatic mechanism, named micro-arousal. Here, we studied the unique progression of the dynamic behavior of cortical and hippocampal local field potentials (LFPs) during slow-wave sleep-related to motor-bursts (micro-arousals) in mice. Our main results comprised: (i) an abrupt drop in hippocampal LFP amplitude preceding micro-arousals which persisted until the end of motor-bursts (we defined as t interval, around 4s) and a similar, but delayed amplitude reduction in cortical (S1/M1) LFP activity occurring at micro-arousal onset; (ii) two abrupt frequency jumps in hippocampal LFP activity: from Theta (6-12 Hz) to Delta (2-4 Hz), also t seconds before the micro-arousal onset, and followed by another frequency jump from Delta to Theta range (5-7 Hz), now occurring at micro-arousal onset; (iii) a pattern of cortico-hippocampal frequency communication precedes micro-arousals: the analysis between hippocampal and cortical LFP fluctuations reveal high coherence during τ interval in a broader frequency band (2-12 Hz), while at a lower frequency band (0.5-2 Hz) the coherence reaches its maximum after the onset of micro-arousals. In conclusion, these novel findings indicate that oscillatory dynamics pattern of cortical and hippocampal LFPs preceding micro-arousals could be part of the regulatory processes in sleep architecture. |
