| Autor: |
Kondoh K; Postgraduate Clinical Training Center, Ehime Prefectural Central Hospital., Michitaka K; Postgraduate Clinical Training Center, Ehime Prefectural Central Hospital.; Gastroenterology Center, Ehime Prefectural Central Hospital., Hiraoka A; Gastroenterology Center, Ehime Prefectural Central Hospital., Izumoto H; Gastroenterology Center, Ehime Prefectural Central Hospital., Ueki H; Gastroenterology Center, Ehime Prefectural Central Hospital., Kitahata S; Gastroenterology Center, Ehime Prefectural Central Hospital., Yamago H; Gastroenterology Center, Ehime Prefectural Central Hospital., Tsubouchi E; Gastroenterology Center, Ehime Prefectural Central Hospital., Ninomiya T; Gastroenterology Center, Ehime Prefectural Central Hospital. |
| Jazyk: |
japonština |
| Zdroj: |
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology [Nihon Shokakibyo Gakkai Zasshi] 2019; Vol. 116 (4), pp. 353-359. |
| DOI: |
10.11405/nisshoshi.116.353 |
| Abstrakt: |
A woman in her 60s visited our hospital due to elevation of ALP (1357U/L). The patient had been treated with lamivudine (LAM) in 2005, LAM+adefovir (ADV) in 2009, and ADV+entecavir in 2015 for chronic hepatitis B (CH-B). The ALP isozyme was predominantly bone type. Urinary β-2 microglobulin (MG) and α-1MG increased to 49635μg/L and 64.1mg/L, respectively. Though no fractures were found during bone scintigraphy, the patient was diagnosed with Fanconi syndrome. However, 3 months after switching from ADV to tenofovir alafenamide (TAF), ALP decreased to 856U/L, and urinary β-2MG and α-1MG decreased to 624μg/L and 6.0mg/L, respectively. Fanconi syndrome should be considered when an increase in ALP is observed in patients treated with ADV, and urinary β-2MG and α-1MG assays are useful for establishing a diagnosis. Switching from ADV to TAF was an effective therapeutic option. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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