Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma.

Autor: Kang M; Department of Pathology Gil Medical Center, Gachon University College of Medicine, Incheon, Korea., Kim NR; Department of Pathology Gil Medical Center, Gachon University College of Medicine, Incheon, Korea., Chung DH; Department of Pathology Gil Medical Center, Gachon University College of Medicine, Incheon, Korea., Yie GT; Department of Neurosurgery, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
Jazyk: angličtina
Zdroj: Journal of pathology and translational medicine [J Pathol Transl Med] 2019 May; Vol. 53 (3), pp. 192-197. Date of Electronic Publication: 2019 Apr 11.
DOI: 10.4132/jptm.2019.03.20
Abstrakt: A 51-year-old woman presented with severe dizziness. The brain magnetic resonance image revealed a 5.5 cm multiloculated mass with a thick rim in the left temporal lobe. Cytological examination of frozen diagnosis of the mass showed hypercellular sheets of round and rhabdoid cells in a hemorrhagic background, and two mitotic figures were observed. Histologically, the excised dura-based mass consisted of predominantly round cells with small foci of rhabdoid tumor cells in a pseudoalveolar pattern in a hemorrhagic background, and the cells showed nuclear positivity for signal transducer and activator of transcription 6 as well as frequent mitosis. The mass was diagnosed as a grade 3 solitary fibrous tumor (SFT)/hemangiopericytoma (HPC). The cytological diagnosis of SFT/HPC is challenging because of the heterogeneous cytological findings, such as histological heterogeneity, and because there are no standardized cytological criteria for malignant SFT/HPC. Cytological findings, such as singly scattered small cells, hypercellularity, rare ropy collagen, and round and rhabdoid cells with pseudoalveolar pattern, may assist in the diagnosis of malignant SFT/HPC.
Databáze: MEDLINE