Inhibitory effect of Bisphenol A on in vitro feline uterine contractions.

Autor: Kabakci R; Kirikkale University, Faculty of Veterinary Medicine, Department of Physiology, Yahsihan 71450, Kirikkale, Turkey. Electronic address: ruhikabakci@kku.edu.tr., Macun HC; Kirikkale University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynecology, Yahsihan 71450, Kirikkale, Turkey., Polat IM; Kirikkale University, Faculty of Veterinary Medicine, Department of Obstetrics and Gynecology, Yahsihan 71450, Kirikkale, Turkey., Yildirim E; Kirikkale University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, Yahsihan 71450, Kirikkale, Turkey.
Jazyk: angličtina
Zdroj: Animal reproduction science [Anim Reprod Sci] 2019 Jun; Vol. 205, pp. 27-33. Date of Electronic Publication: 2019 Mar 27.
DOI: 10.1016/j.anireprosci.2019.03.017
Abstrakt: Bisphenol A (BPA) is an environmental pollutant used as a plasticizer in the manufacture of many plastic products, such as packaging, containers, and water and beverage bottles. There are deleterious effects of BPA on metabolic, endocrine, nervous, and reproductive systems. This is the first study in which there was investigation of the in vitro effect of BPA on the spontaneous contractions of the cat uterus. The tubal uterine segments (1 cm) collected from queens in estrus were suspended in an isolated organ bath. Following tissue stabilization, spontaneous contractions were recorded for 10 min to constitute the control group. The effects of the solvent (alcohol) and BPA at different concentrations (1, 10, and 100 μM) on uterine contractions were subsequently evaluated at 10 min intervals in terms of frequency and mean amplitude variables. The ethanol vehicle did not alter the uterine contractions compared to the control group. All concentrations of BPA used in the study resulted in a reduction (P < 0.05) in amplitude of uterine contractions in a dose-dependent manner, while only the largest dose of BPA decreased the frequency of contractions (P < 0.05). In reproductive physiology, regular uterine contractions facilitate successful fertilization, migration, implantation, and maintenance of pregnancy, as well as fetus expulsion. The results of this study indicate BPA has an inhibitory effect on spontaneous contractions of the cat uterus. It is proposed that this suppressive effect of BPA on uterine contractions might lead to queen infertility.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: