Sacrificial Bioprinting of a Mammary Ductal Carcinoma Model.

Autor: Duchamp M; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Department of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, 1015, Switzerland., Liu T; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Center of Clinical Experiments, Changhai Hospital, Second Military Medical University, Shanghai, 200433, P. R. China., van Genderen AM; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CG, Utrecht, The Netherlands., Kappings V; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.; Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, 76131, Karlsruhe, Germany., Oklu R; Division of Vascular and Interventional Radiology, Mayo Clinic, Scottsdale, AZ, 85259, USA., Ellisen LW; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, 02114, USA., Zhang YS; Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Jazyk: angličtina
Zdroj: Biotechnology journal [Biotechnol J] 2019 Oct; Vol. 14 (10), pp. e1700703. Date of Electronic Publication: 2019 May 27.
DOI: 10.1002/biot.201700703
Abstrakt: Cancer tissue engineering has remained challenging due to the limitations of the conventional biofabrication techniques to model the complex tumor microenvironment. Here, the utilization of a sacrificial bioprinting strategy is reported to generate the biomimetic mammary duct-like structure within a hydrogel matrix, which is further populated with breast cancer cells, to model the genesis of ductal carcinoma and its subsequent outward invasion. This bioprinted mammary ductal carcinoma model provides a proof-of-concept demonstration of the value of using the sacrificial bioprinting technique for engineering biologically relevant cancer models, which may be possibly extended to other cancer types where duct-like structures are involved.
(© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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