Toxic Effects of Particulate Matter Derived from Dust Samples Near the Dzhidinski Ore Processing Mill, Eastern Siberia, Russia.

Autor: Zychowski KE; Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM, 87131, USA., Wheeler A; Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM, 87131, USA., Sanchez B; Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM, 87131, USA., Harmon M; Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM, 87131, USA., Steadman Tyler CR; Bioscience Division, Los Alamos National Laboratories, Los Alamos, NM, 87545, USA., Herbert G; Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM, 87131, USA., Lucas SN; Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM, 87131, USA., Ali AM; Department of Civil Engineering, University of New Mexico, Albuquerque, NM, 87131, USA., Avasarala S; Department of Civil Engineering, University of New Mexico, Albuquerque, NM, 87131, USA., Kunda N; Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM, 87131, USA., Robinson P; Southwest Research and Information Center, Albuquerque, NM, 87196, USA., Muttil P; Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM, 87131, USA., Cerrato JM; Department of Civil Engineering, University of New Mexico, Albuquerque, NM, 87131, USA., Bleske B; Pharmacy Practice and Administrative Sciences, University of New Mexico-Health Sciences Center, Albuquerque, NM, 87131, USA., Smirnova O; Geological Institute, Siberian Branch, Russian Academy of Sciences, Moscow, Russia., Campen MJ; Department of Pharmaceutical Sciences, University of New Mexico-Health Sciences Center, MSC09 5360, Albuquerque, NM, 87131, USA. mcampen@salud.unm.edu.
Jazyk: angličtina
Zdroj: Cardiovascular toxicology [Cardiovasc Toxicol] 2019 Oct; Vol. 19 (5), pp. 401-411.
DOI: 10.1007/s12012-019-09507-y
Abstrakt: Ambient particulate matter (PM) is associated with increased mortality and morbidity, an effect influenced by the metal components of the PM. We characterized five sediment samples obtained near a tungsten-molybdenum ore-processing complex in Zakamensk, Russia for elemental composition and PM toxicity with regard to pulmonary, vascular, and neurological outcomes. Elemental and trace metals analysis of complete sediment and PM 10 (the respirable fraction, < 10 µm mass mean aerodynamic diameter) were performed using inductively coupled plasma optical emission spectrometry (ICP-OES) and mass spectrometry (ICP-MS). Sediment samples and PM 10 consisted largely of silicon and iron and silicon and sodium, respectively. Trace metals including manganese and uranium in the complete sediment, as well as copper and lead in the PM 10 were observed. Notably, metal concentrations were approximately 10 × higher in the PM 10 than in the sediment. Exposure to 100 µg of PM 10 via oropharyngeal aspiration in C56BL/6 mice resulted in pulmonary inflammation across all groups. In addition, mice exposed to three of the five PM 10 samples exhibited impaired endothelial-dependent relaxation, and correlative analysis revealed associations between pulmonary inflammation and levels of lead and cadmium. A tendency for elevated cortical ccl2 and Tnf-α mRNA expression was induced by all samples and significant upregulation was noted following exposure to PM 10 samples Z3 and Z4, respectively. Cortical Nqo1 mRNA levels were significantly upregulated in mice exposed to PM 10 Z2. In conclusion, pulmonary exposure to PM samples from the Zakamensk region sediments induced varied pulmonary and systemic effects that may be influenced by elemental PM composition. Further investigation is needed to pinpoint putative drivers of neurological outcomes.
Databáze: MEDLINE
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