| Autor: |
Mahmoud AM; Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, Egypt., Hernández Bautista RJ; Metropolitan Autonomous University, Laboratory of Bioenergetics and Cellular Aging, Department of Health Sciences, Division of Health and Biological Sciences, Mexico., Sandhu MA; Biomedical Sciences Department, Faculty of Veterinary & Animal Sciences, PMAS Arid Agriculture University, Pakistan., Hussein OE; Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, Egypt. |
| Jazyk: |
angličtina |
| Zdroj: |
Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2019 Mar 10; Vol. 2019, pp. 5484138. Date of Electronic Publication: 2019 Mar 10 (Print Publication: 2019). |
| DOI: |
10.1155/2019/5484138 |
| Abstrakt: |
The prevalence of cardiovascular disease (CVD) is increasing over time. CVD is a comorbidity in diabetes and contributes to premature death. Citrus flavonoids possess several biological activities and have emerged as efficient therapeutics for the treatment of CVD. Citrus flavonoids scavenge free radicals, improve glucose tolerance and insulin sensitivity, modulate lipid metabolism and adipocyte differentiation, suppress inflammation and apoptosis, and improve endothelial dysfunction. The intake of citrus flavonoids has been associated with improved cardiovascular outcomes. Although citrus flavonoids exerted multiple beneficial effects, their mechanisms of action are not completely established. In this review, we summarized recent findings and advances in understanding the mechanisms underlying the protective effects of citrus flavonoids against oxidative stress, inflammation, diabetes, dyslipidemia, endothelial dysfunction, and atherosclerosis. Further studies and clinical trials to assess the efficacy and to explore the underlying mechanism(s) of action of citrus flavonoids are recommended. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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