A Novel VIM-Type Metallo-β-Lactamase Variant, VIM-60, with Increased Hydrolyzing Activity against Fourth-Generation Cephalosporins in Pseudomonas aeruginosa Clinical Isolates in Japan.

Autor: Hishinuma T; Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan., Tada T; Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan t-tada@juntendo.ac.jp., Uchida H; Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan., Shimojima M; BML, Inc., Kawagoe, Saitama, Japan., Kirikae T; Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Jazyk: angličtina
Zdroj: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 May 24; Vol. 63 (6). Date of Electronic Publication: 2019 May 24 (Print Publication: 2019).
DOI: 10.1128/AAC.00124-19
Abstrakt: A novel VIM-type metallo-β-lactamase variant, VIM-60, was identified in multidrug-resistant Pseudomonas aeruginosa clinical isolates in Japan. Compared with VIM-2, VIM-60 had two amino acid substitutions (Arg228Leu and His252Arg) and higher catalytic activities against fourth-generation cephalosporins. The genetic context for bla VIM-60 was intI1-bla VIM-60 - aadA1-aacA31-qacEdeltaI-sulI on the chromosome.
(Copyright © 2019 American Society for Microbiology.)
Databáze: MEDLINE
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