False-positive acetylcholine receptor antibody results in patients without myasthenia gravis.

Autor: Maddison P; Department of Clinical Neurology, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK. Electronic address: paul.maddison@nhs.net., Sadalage G; Department of Clinical Neurology, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK., Ambrose PA; Department of Clinical Neurology, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK., Jacob S; Queen Elizabeth Neuroscience Centre and Centre for Rare Diseases, University Hospitals Birmingham, B15 2TH, UK., Vincent A; Nuffield Department of Clinical Neurosciences,West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2019 Jul 15; Vol. 332, pp. 69-72. Date of Electronic Publication: 2019 Apr 03.
DOI: 10.1016/j.jneuroim.2019.04.001
Abstrakt: Acetylcholine receptor antibodies are very specific for myasthenia. During a large prospective cohort study of myasthenia, we encountered five patients, positive for acetylcholine receptor (AChR) antibodies by radioimmunoprecipitation assay (RIA), whose clinical course revealed diagnoses other than myasthenia. Two patients had transiently raised AChR antibodies associated with Guillain-Barré syndrome. Antibodies to clustered AChRs, in a live cell-based assay, were negative in all five patients, suggesting that results from the RIAs were false-positives. It is possible that the AChR antibodies detected by RIA in these cases were non-pathogenic, and directed to intracellular epitopes of the AChR.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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