Outbreak of Brucella melitensis infection in Eastern Sicily: risk factors, clinical characteristics and complication rate.

Autor:	Cama BAV; Department of Clinical and Experimental Medicine, Unit of Infectious Disease, University of Messina, Italy., Ceccarelli M; Department of Clinical and Experimental Medicine, Unit of Infectious Disease, University of Messina, Italy., Venanzi Rullo E; Department of Clinical and Experimental Medicine, Unit of Infectious Disease, University of Messina, Italy.; Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Ferraiolo F; Department of Clinical and Experimental Medicine, Unit of Infectious Disease, University of Messina, Italy., Paolucci IA; Department of Clinical and Experimental Medicine, Unit of Infectious Disease, University of Messina, Italy.; Department of Specialized Medicine, Unit of Infectious Diseases, University Hospital 'G. Martino', Messina, Italy., Maranto D; Department of Specialized Medicine, Unit of Infectious Diseases, University Hospital 'G. Martino', Messina, Italy., Mondello P; Department of Specialized Medicine, Unit of Infectious Diseases, University Hospital 'G. Martino', Messina, Italy., Lo Presti Costantino MR; Department of Specialized Medicine, Unit of Infectious Diseases, University Hospital 'G. Martino', Messina, Italy., Marano F; Department of Prevention, Provincial Health Authority Messina, Italy., D'Andrea G; Department of Prevention, Provincial Health Authority Messina, Italy., Di Marco V; Zoo-prophylactic Experimental Institute of Sicily, Barcellona P.G. (ME), Italy., Puglisi G; Department of Prevention, Provincial Health Authority Messina, Italy., Valenzise M; Department of Human Pathology of Adult and Developmental Age 'Gaetano Barresi', University of Messina, Italy., D'Angelo G; Department of Human Pathology of Adult and Developmental Age 'Gaetano Barresi', University of Messina, Italy., Mondello L; Unit of Infectious Diseases, 'Papardo' Hospital, Messina, Italy., Strano G; Unit of Infectious Diseases, 'Papardo' Hospital, Messina, Italy., Condorelli F; Department of Pharmacological Sciences, Università del Piemonte Orientale 'A. Avogadro', Novara, Italy., Spicola D; Department of Specialized Medicine, Unit of Infectious Diseases, University Hospital 'G. Martino', Messina, Italy., Nunnari G; Department of Clinical and Experimental Medicine, Unit of Infectious Disease, University of Messina, Italy., Pellicanò GF; Department of Human Pathology of Adult and Developmental Age 'Gaetano Barresi', University of Messina, Italy.
Jazyk:	angličtina
Zdroj:	The new microbiologica [New Microbiol] 2019 Jan; Vol. 42 (1), pp. 43-48.
Abstrakt:	Brucellosis is one of the most common zoonoses in the world, especially in Southern Italy, where many cases are still recorded every year. 128 cases of brucellosis were observed in Messina (Sicily) in 2016, representing a tenfold increase in the number of cases of brucellosis expected. The aim of this multicenter retrospective study was to analyze clinical and microbiological aspects of a brucellosis outbreak in the province of Messina in 2016, the incidence of its complications and the treatment combinations applied. The principal transmission route was through the ingestion of unpasteurized fresh cheese. The mean latency period between the onset of the symptoms and diagnosis was 35.58±42.75 days. A late diagnosis increases the risk of developing complications. Drug-resistant strains of B. melitensis to Trimethoprim/ Sulfamethoxazole and Ciprofloxacin were found in blood cultures of 58.4% patients. Brucellosis is still present in Sicily. A diagnostic delay predisposes to complications requiring prolonged therapies. The finding of Brucella melitensis strains resistant to the most widespread treatments is worrisome and needs further investigation. Moreover, the use of alternative combination antibiotic therapy is recommended.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu