Nasal Polyposis: More than a Chronic Inflammatory Disorder-A Disease of Mechanical Dysfunction-The São Paulo Position.

Autor:	Pezato R; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Voegels RL; Department of Otolaryngology, USP, São Paulo, SP, Brazil., Pignatari S; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Gregório LC; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Pinto Bezerra TF; Department of Otolaryngology, UFPE, Recife, PE, Brazil., Gregorio L; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Balsalobre L; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Tepedino MS; Department of Otolaryngology, UERJ, Rio de Janeiro, RJ, Brazil., Coronel N; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Pinna FR; Department of Otolaryngology, USP, São Paulo, SP, Brazil., Mendes Neto J; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Oliveira P; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Macoto E; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Stefanini R; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Figueiredo C; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Haddad F; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Pilan R; Department of Otolaryngology, USP, São Paulo, SP, Brazil., Bezerra Soter A; Department of Otolaryngology, USP, São Paulo, SP, Brazil., Melo NA; Department of Otolaryngology, USP, São Paulo, SP, Brazil., Candido DA; Department of Medicine, Nephrology Division, Unifesp, São Paulo, SP, Brazil., Amaral JD; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Santos RP; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Van Zele T; Ear, Nose and Throat Department,, University of Ghent, Ghent, Belgium., Fujita R; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil., Dreyfuss JL; Department of Biochemistry, Unifesp, São Paulo, SP, Brazil., Chamon W; Department of Ophthalmology and Visual Sciences, Unifesp, São Paulo, SP, Brazil.; Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, IL, United States., Alencar AM; Laboratory of Microrheology and Molecular Physiology, Institute of Physics, USP, São Paulo, SP, Brazil., Perez-Novo C; Proteinscience, Proteomics and Epigenetic Signaling, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Stamm AC; Department of Otolaryngology - Head and Neck Surgery, Unifesp, São Paulo, SP, Brazil.
Jazyk:	angličtina
Zdroj:	International archives of otorhinolaryngology [Int Arch Otorhinolaryngol] 2019 Apr; Vol. 23 (2), pp. 241-249. Date of Electronic Publication: 2019 Mar 01.
DOI:	10.1055/s-0038-1676659
Abstrakt:	Introduction  The importance of our study lies in the fact that we have demonstrated the occurrence of mechanical dysfunction within polypoid tissues, which promotes the development of polyps in the nasal cavity. Objective  To change the paradigm of nasal polyposis (NP). In this new conception, the chronic nasal inflammatory process that occurs in response to allergies, to pollution, to changes in the epithelial barrier, or to other factors is merely the trigger of the development of the disease in individuals with a genetic predisposition to an abnormal tissue remodeling process, which leads to a derangement of the mechanical properties of the nasal mucosa and, consequently, allows it to grow unchecked. Data Synthesis  We propose a fundamentally new approach to intervening in the pathological process of NP, addressing biomechanical properties, fluid dynamics, and the concept of surface tension. Conclusion  The incorporation of biomechanical knowledge into our understanding of NP provides a new perspective to help elucidate the physiology and the pathology of nasal polyps, and new avenues for the treatment and cure of NP.
Databáze:	MEDLINE
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