Complement receptor-associated CD163 + /CD18 + /CD11c + /CD206 - /CD209 - expression profile in chronic histiocytic intervillositis of the placenta.

Autor: Hussein K; Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. Electronic address: Hussein.Kais@MH-Hannover.de., Stucki-Koch A; Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany., Müller AM; Praxis für Pathologie/Zentrum für Kinderpathologie Am Universitätsklinikum Köln, Kerpener Str. 62, 50937, Köln, Germany., Arnold R; Pathologisch-Bakteriologisches Institut, SMZ-Ost Donauspital, Langobardenstraße 122, 1220, Wien, Austria., Kreipe H; Institute of Pathology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany., Feist H; Institut für Pathologie, Ev.-Luth. Diakonissenanstalt zu Flensburg, Knuthstr. 1, 24939, Flensburg, Germany.
Jazyk: angličtina
Zdroj: Placenta [Placenta] 2019 Mar; Vol. 78, pp. 23-28. Date of Electronic Publication: 2019 Feb 15.
DOI: 10.1016/j.placenta.2019.02.007
Abstrakt: Introduction: Chronic histiocytic intervillositis of unknown etiology (CIUE) is a non-infectious, most probably immunologic placenta lesion. CIUE is associated with recurrent miscarriage, intrauterine growth restriction and stillbirth. Among the pathologic-anatomic defined placental lesions this entity displays the highest risk of recurrence in following pregnancies (about 67-100%). The histiocytic cells accumulate in the placental blood space but do not infiltrate into the villi or decidua. Sparsely known is the expression profile of these intervillous cells regarding histiocytic markers.
Methods: We analysed 5-22 markers by immunohistochemistry in a total of 41 placenta samples and evaluated decidual, villous and intervillous histiocytic cells.
Results: In CIUE, intervillous CD163 +  histiocytes over-express CD11c/CD18 and down-regulate CD206/CD209, while CD163 +  decidual and Hofbauer cells show low CD11c/CD18 and higher CD206/CD209 protein expressions.
Discussion: CD163 expression indicates a M2-like polarisation. CD11c and CD18 form the complement receptor 4 which could be related to a complement mediated trigger for aberrant cell accumulation in CIUE.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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