Gap 2 phase: making the fundamental decision to divide or not.

Autor: Umeda M; Graduate School of Science and Technology, Nara Institute of Science and Technology, Takayama 8916-5, Ikoma, Nara 630-0192, Japan. Electronic address: mumeda@bs.naist.jp., Aki SS; Graduate School of Science and Technology, Nara Institute of Science and Technology, Takayama 8916-5, Ikoma, Nara 630-0192, Japan., Takahashi N; Graduate School of Science and Technology, Nara Institute of Science and Technology, Takayama 8916-5, Ikoma, Nara 630-0192, Japan.
Jazyk: angličtina
Zdroj: Current opinion in plant biology [Curr Opin Plant Biol] 2019 Oct; Vol. 51, pp. 1-6. Date of Electronic Publication: 2019 Apr 05.
DOI: 10.1016/j.pbi.2019.03.001
Abstrakt: The Gap phases of the cell cycle are essential to perceive internal and external signals and control cell division and differentiation. However, our knowledge of molecular mechanisms underlying G2 progression in plants remains quite limited. In this review, we summarize recent findings about core G2-phase regulators, such as B-type cyclin-dependent kinases (CDKs) and R1R2R3-type MYB transcription factors. We highlight developmental and stress signals that regulate expression and accumulation of the G2-phase regulators, and discuss how they fine-tune mitotic CDK activity and control cell proliferation, endoreplication and cell cycle checkpoints. A particular focus is on DNA damage-induced G2 arrest, which is prerequisite for maintenance of genome stability.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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