Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.

Autor:	Ranasinghe KG; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, 94158, USA. Kamalini.ranasinghe@ucsf.edu., Kothare H; Speech Neuroscience Laboratory, Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, CA, 94143, USA.; Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94143, USA.; UC Berkeley - UCSF, Graduate Program in Bioengineering, San Francisco, CA, USA., Kort N; Speech Neuroscience Laboratory, Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, CA, 94143, USA.; Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94143, USA., Hinkley LB; Speech Neuroscience Laboratory, Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, CA, 94143, USA.; Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94143, USA., Beagle AJ; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, 94158, USA., Mizuiri D; Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94143, USA., Honma SM; Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94143, USA., Lee R; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, 94158, USA., Miller BL; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, 94158, USA., Gorno-Tempini ML; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, 94158, USA., Vossel KA; Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, 94158, USA.; N. Bud Grossman Center for Memory Research and Care, Institute for Translational Neuroscience, and Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA., Houde JF; Speech Neuroscience Laboratory, Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, CA, 94143, USA., Nagarajan SS; Speech Neuroscience Laboratory, Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, CA, 94143, USA.; Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, 94143, USA.
Jazyk:	angličtina
Zdroj:	Scientific reports [Sci Rep] 2019 Apr 05; Vol. 9 (1), pp. 5686. Date of Electronic Publication: 2019 Apr 05.
DOI:	10.1038/s41598-019-41794-x
Abstrakt:	Accurate integration of sensory inputs and motor commands is essential to achieve successful behavioral goals. A robust model of sensorimotor integration is the pitch perturbation response, in which speakers respond rapidly to shifts of the pitch in their auditory feedback. In a previous study, we demonstrated abnormal sensorimotor integration in patients with Alzheimer's disease (AD) with an abnormally enhanced behavioral response to pitch perturbation. Here we examine the neural correlates of the abnormal pitch perturbation response in AD patients, using magnetoencephalographic imaging. The participants phonated the vowel /α/ while a real-time signal processor briefly perturbed the pitch (100 cents, 400 ms) of their auditory feedback. We examined the high-gamma band (65-150 Hz) responses during this task. AD patients showed significantly reduced left prefrontal activity during the early phase of perturbation and increased right middle temporal activity during the later phase of perturbation, compared to controls. Activity in these brain regions significantly correlated with the behavioral response. These results demonstrate that impaired prefrontal modulation of speech-motor-control network and additional recruitment of right temporal regions are significant mediators of aberrant sensorimotor integration in patients with AD. The abnormal neural integration mechanisms signify the contribution of cortical network dysfunction to cognitive and behavioral deficits in AD.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.