Infantile Anaphylaxis in Korea: a Multicenter Retrospective Case Study.
| Autor: | Jeon YH; Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea., Lee S; Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea. jsjs87@ajou.ac.kr., Ahn K; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Lee SY; Department of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Kim KW; Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Kim HH; Department of Pediatrics, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea., Kim JH; Department of Pediatrics, Inha University Hospital, Inha University College of Medicine, Incheon, Korea., Yum HY; Department of Pediatrics, Seoul Medical Center, Seoul, Korea., Kim WK; Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Seoul, Korea., Park YM; Department of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea., Song TW; Department of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Seoul, Korea., Kim J; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Lee YJ; Department of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea., Jang GC; Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Seoul, Korea., Jeong K; Department of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea., Kim YH; Department of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Min TK; Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea., Pyun BY; Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea. bypyun@schmc.ac.kr. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of Korean medical science [J Korean Med Sci] 2019 Apr 08; Vol. 34 (13), pp. e106. Date of Electronic Publication: 2019 Apr 08. |
| DOI: | 10.3346/jkms.2019.34.e106 |
| Abstrakt: | Background: Anaphylaxis is increasing in young children. The aim of the present study was to analyze the clinical characteristics of anaphylaxis in Korean infants, with a focus on food triggers. Methods: The study analyzed the medical records of infants aged 0 to 2 years old who had been diagnosed with anaphylaxis in 23 secondary or tertiary hospitals in Korea. Results: We identified 363 cases of infantile anaphylaxis (66.9% male). Cutaneous symptoms were most prevalent (98.6%), followed by respiratory (83.2%), gastrointestinal (29.8%), and neurologic (11.6%) symptoms. Cardiovascular symptoms were noted in 7.7% of the cases. Most of the cases of anaphylaxis (338; 93.1%) were induced by foods. The most common trigger food was cow's milk and cow's milk products (43.8%), followed by hen's eggs (21.9%), walnuts (8.3%), wheat (7.7%), peanuts (4.8%), other nuts (3.0%), and fish (2.1%). In cow's milk-induced anaphylaxis cases, more than half the cases had cow's milk specific immunoglobulin E (sIgE) levels that were lower than the diagnostic decision points (DDPs), which is 5 kU Conclusion: Cow's milk is the most frequent trigger food of anaphylaxis in Korean infants. However, we found no significant correlation between the sIgE level and clinical severity. Education is required regarding the importance of epinephrine as the first line therapy for anaphylaxis and on properly prescribing epinephrine for infants with a history of anaphylaxis. Competing Interests: The authors have no potential conflicts of interest to disclose. (© 2019 The Korean Academy of Medical Sciences.) |
| Databáze: | MEDLINE |
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